换一批
换一批Tumor stroma-derived factors skew monocyte to dendritic cell differentiation toward a suppressive CD14<sup>+</sup> PD-L1<sup>+</sup> phenotype in prostate cancer.
作者：
关键词
CCL2CCL2, (C–C) motif chemokine ligand-2CFSE, carboxyfluorescein succinimidyl esterCK, cytokeratinCM, conditioned mediaCXCL, chemokine (C–X–C) motifDC, dendritic cellELISA, enzyme-linked immunosorbent assayGM-CSF, granulocyte macrophage colony-stimulating factorHFF, human foreskin fibroblastHGF, hepatocyte growth factorI-TAC, interferon-inducible T cell α chemoattractantIFN, interferonIL, interleukinIL-6IP-10, interferon-γ induced protein 10LPS, lipopolysaccharideMIF, macrophage inhibitory factorPBMC, peripheral blood mononuclear cellsPCaEp, prostate cancer epitheliaPCaSt, prostate cancer stromaPD-1, programmed cell death-1PD-L1PD-L1, programmed cell death ligand-1RANTES/CCL5, regulated on activation, normal T cell expressed and secretedSCBM, stromal cell basal mediaSDF-1, stromal-derived factor-1STAT3STAT3, signal transducer and activator of transcription 3TGFβ, transforming growth factor βTIL, tumor infiltrating leukocytesVEGF, vascular endothelial growth factorantigen cross-presentationdendritic cellsimmunosuppressionprostate cancersDC, DC generated in the presence of 50 PCaSt-CMtumor microenvironmenttumor stromaα-SMA, α-smooth muscle actin
DOI
10.4161/21624011.2014.955331
PMID
25941611
发布时间
2021-02-03
- 浏览84
Oncoimmunology
e955331页
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