Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy.
第一作者:
Yin,Shi
第一单位:
a Department of Physiology; Yong Loo Lin School of Medicine; National University of Singapore ; Singapore.
作者:
关键词
ATP6V0D1, ATPase H+ transporting lysosomal 38kDa, V0 subunit d1Baf, bafilomycin A1CAV1, caveolin 1CHO, water-soluble cholesterolCQ, choloroquineCTSL, cathepsin LCTxB, cholera toxin subunit BDRF, detergent-resistant fractionDSF, detergent-soluble fractionEGF, epidermal growth factorKO, knockoutLAMP1, lysosomal-associated membrane protein 1MAP1LC3/LC3, microtubule-associated protein 1 light chain 3MBCD, methyl-β-cyclodextrinMEF, mouse embryonic fibroblastsMTOR, mechanistic target of rapamycinPBS, phosphate-buffered salinePI, propidium iodidePLA, proximity ligation assayPTRF, polymerase I and transcript release factorTFRC, transferrin receptorTSC, tuberous sclerosis complexWT, wild type.autophagybreast cancercaveolin 1lipid raftslysosometfLC3B, mRFP-GFP tandem fluorescent-tagged LC3B
医学主题词
动物(Animals);自噬(Autophagy);乳腺肿瘤(Breast Neoplasms);窖蛋白1(Caveolin 1);细胞存活(Cell Survival);减量调节(Down-Regulation);女(雌)性(Female);人类(Humans);溶酶体(Lysosomes);膜融合(Membrane Fusion);膜微区(Membrane Microdomains);小鼠(Mice);模型, 生物学(Models, Biological);吞噬体(Phagosomes);应激, 生理学(Stress, Physiological);空泡质子转运ATP酶(Vacuolar Proton-Translocating ATPases)
DOI
10.1080/15548627.2015.1034411
PMID
25945613
发布时间
2018-11-13
- 浏览42
Autophagy
769-84页
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