换一批
换一批Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy.
第一作者：
Oana,Draghiciu
第一单位：
Department of Medical Microbiology; Tumor Virology and Cancer Immunotherapy; University of Groningen; University Medical Center Groningen ; Groningen, The Netherlands.
作者：
关键词
5-FU, 5-fluorouracil5-FluorouracilADAM17, metalloproteinase domain-containing protein 17APCs, antigen presenting cellsARG1, arginase-1ATRA, all-trans retinoic acidCCL2, chemokine (C-C motif) ligand 2CD62L, L-selectinCDDO-Me, bardoxolone methylCOX2, cyclooxygenase 2CTLs, cytotoxic T lymphocytesCXCL12, chemokine (C-X-C motif) ligand 12CXCL15, chemokine (C-X-C motif) ligand 15DCs, dendritic cellsERK1/2, extracellular signal-regulated kinasesFlt3, Fms-like tyrosine kinase 3FoxP3, forkhead box P3GITR, anti-glucocorticoid tumor necrosis factor receptorGM-CSF/CSF2, granulocyte monocyte colony stimulating factorGSH, glutathioneHIF-1α, hypoxia inducible factor 1αHLA, human leukocyte antigenHNSCC, head and neck squamous cell carcinomaHPV-16, human papillomavirus 16HSCs, hematopoietic stem cellsICT, 3, 5, 7-trihydroxy-4′-emthoxy-8-(3-hydroxy-3-methylbutyl)-flavoneIFNγ, interferon γIL-10, interleukin 10IL-13, interleukin 13IL-1β, interleukin 1 βIL-4, interleukin 4IL-6, interleukin 6IMCs, immature myeloid cellsJAK2, Janus kinase 2MDSCs, myeloid-derived suppressor cellsMMPs, metalloproteinases (e.g., MMP9)Myd88, myeloid differentiation primary response protein 88NAC, N-acetyl cysteineNADPH, nicotinamide adenine dinucleotide phosphate-oxidase NK cells, natural killer cellsNO, nitric oxideNOHA, N-hydroxy-L-ArginineNSAID, nonsteroidal anti-inflammatory drugsODN, oligodeoxynucleotidesPDE-5, phosphodiesterase type 5PGE2, prostaglandin E2RNS, reactive nitrogen speciesROS, reactive oxygen speciesSCF, stem cell factorSTAT3, signal transducer and activator of transcription 3TAMs, tumor-associated macrophagesTCR, T cell receptorTGFβ, transforming growth factor βTNFα, tumor necrosis factor αTregs, regulatory T cellsVEGFR, vascular endothelial growth factor receptorWA, withaferin AWRE, Withaferin somniferaall-trans retinoic acidbisphosphonatesc-kit, Mast/stem cell growth factor receptorgemcitabineiNOS2, inducible nitric oxid synthase 2immune suppressive mechanismsmRCC, metastatic renal cell carcinomamyeloid-derived suppressor cellssunitinib therapeutic vaccination
DOI
10.4161/21624011.2014.954829
PMID
25949858
发布时间
2022-03-18
- 浏览6
Oncoimmunology
e954829页
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