Low miR-145 silenced by DNA methylation promotes NSCLC cell proliferation, migration and invasion by targeting mucin 1.
作者:
关键词
5-aza-20-deoxycytidine, 5-AzaCCK-8, Cell Counting Kit-8GAPDH, glyceraldehydes phosphate dehydrogenaseHBE, human bronchial epithelial cell lineMSP, Methylation-specific PCRNSCLC, non–small cell lung cancerSqCC, squamous cell cancerinvasionmethylationmiR-145migrationmucin 1non–small cell lung cancerproliferation
主题词
3'非翻译区(3' Untranslated Regions);碱基序列(Base Sequence);印迹法, 蛋白质(Blotting, Western);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);DNA甲基化(DNA Methylation);减量调节(Down-Regulation);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);Kaplan-Meiers评估(Kaplan-Meier Estimate);肺肿瘤(Lung Neoplasms);男(雄)性(Male);微RNAs(MicroRNAs);中年人(Middle Aged);黏蛋白-1(Mucin-1);多元分析(Multivariate Analysis);肿瘤侵润(Neoplasm Invasiveness);预后(Prognosis);比例危险度模型(Proportional Hazards Models);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction)
DOI
10.1080/15384047.2015.1046024
PMID
25961369
发布时间
2022-04-10
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Cancer biology & therapy
1071-9页
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