Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.

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第一作者： Agnieszka,Zagórska

第一单位： Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland. Electronic address: agnieszka.zagorska@uj.edu.pl.

作者： Agnieszka,Zagórska ^[1] ; Marcin,Kołaczkowski ^[2] ; Adam,Bucki ^[2] ; Agata,Siwek ^[3] ; Grzegorz,Kazek ^[4] ; Grzegorz,Satała ^[5] ; Andrzej J,Bojarski ^[5] ; Anna,Partyka ^[6] ; Anna,Wesołowska ^[6] ; Maciej,Pawłowski ^[2]

作者单位： Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland. Electronic address: agnieszka.zagorska@uj.edu.pl. ^[1] Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland. ^[2] Department of Pharmacobiology, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland. ^[3] Departament of Pharmacodynamics, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland. ^[4] Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of, Sciences, 12 Smętna Street, 31-343 Kraków, Poland. ^[5] Department of Clinical Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland. ^[6]

关键词 Depression Imidazo[2,1-f]purine-2,4-diones Long-chain arylpiperazines Schizophrenia Serotonin Tricyclic theophylline derivatives