Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids.

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第一作者： Pedro,Escoll

第一单位： Department of Medicine, School of Medicine, Alcala University (UAH), Alcalá de Henares, 28805 Madrid, Spain ; Biologie des Bactéries Intracellulaires, Departement Genomes et Génétique, Institut Pasteur, 75015 Paris, France.

作者： Pedro,Escoll ^[1] ; Ismael,Ranz ^[2] ; Norman,Muñoz-Antón ^[3] ; Ana,van-den-Rym ^[3] ; Melchor,Alvarez-Mon ^[4] ; Carlos,Martínez-Alonso ^[5] ; Eva,Sanz ^[4] ; Antonio,de-la-Hera ^[3]

作者单位： Department of Medicine, School of Medicine, Alcala University (UAH), Alcalá de Henares, 28805 Madrid, Spain ; Biologie des Bactéries Intracellulaires, Departement Genomes et Génétique, Institut Pasteur, 75015 Paris, France. ^[1] Immunology and Individualized Medicine, IMMPA CSIC/UAH Joint Unit, Alcalá de Henares, 28805 Madrid, Spain ; MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, Division of Asthma, Allergy & Lung Biology, 5th Floor Tower Wing, Guy's Hospital, London SE1 9RT, UK. ^[2] Immunology and Individualized Medicine, IMMPA CSIC/UAH Joint Unit, Alcalá de Henares, 28805 Madrid, Spain. ^[3] Department of Medicine, School of Medicine, Alcala University (UAH), Alcalá de Henares, 28805 Madrid, Spain. ^[4] Department of Immunology and Oncology, National Biotechnology Center, Spanish National Research Council (CNB-CSIC), 28049 Madrid, Spain. ^[5]

主题词印迹法, 蛋白质(Blotting, Western);细胞系(Cell Line);荧光抗体技术(Fluorescent Antibody Technique);糖皮质激素类(Glucocorticoids);人类(Humans);胰岛素样生长因子结合蛋白质1(Insulin-Like Growth Factor Binding Protein 1);干扰素调节因子类(Interferon Regulatory Factors);白细胞介素1β(Interleukin-1beta);磷酰化(Phosphorylation);受体, 糖皮质激素(Receptors, Glucocorticoid);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);他克莫司结合蛋白质类(Tacrolimus Binding Proteins);Tristetraprolin蛋白(Tristetraprolin)

DOI 10.1155/2015/347965

PMID 25977599

发布时间 2018-11-13

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Mediators of inflammation

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Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids.

Mediators of inflammation

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Mediators of inflammation

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Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids.

Mediators of inflammation

相似文献

Mediators of inflammation

相关期刊

检索历史清除