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首页> Cerebral cortex (New York, N.Y. : 1991)> Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

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作者： Francesco,Bedogni ^[1] ; Clementina,Cobolli Gigli ^[1] ; Davide,Pozzi ^[2] ; Riccardo Lorenzo,Rossi ^[3] ; Linda,Scaramuzza ^[4] ; Grazisa,Rossetti ^[1] ; Massimiliano,Pagani ^[4] ; Charlotte,Kilstrup-Nielsen ^[4] ; Michela,Matteoli ^[2] ; Nicoletta,Landsberger ^[3]

作者单位： San Raffaele Rett Research Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy. ^[1] Laboratory of Genetic and Epigenetic Control of Gene Expression, Division of Biomedical Research, Department of Theoretical and Applied Sciences, University of Insubria, Busto Arsizio, 21052 Varese, Italy. ^[2] Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Rozzano, 20089 Milan, Italy. ^[3] Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi", 20122 Milan, Italy. ^[4] Dip di Biotecnologie Mediche e Medicina Traslazionale, Università di Milano, Milan, Italy. ^[5]

关键词 MeCP2 null cortex embryonic cerebral cortex development intrinsic neuronal excitability neurological disorders transcriptome

主题词动物(Animals);钙(Calcium);细胞运动(Cell Movement);细胞, 培养的(Cells, Cultured);大脑皮质(Cerebral Cortex);疾病恶化(Disease Progression);电刺激(Electric Stimulation);荧光抗体技术(Fluorescent Antibody Technique);谷氨酸(Glutamic Acid);甲基-CpG-结合蛋白质2(Methyl-CpG-Binding Protein 2);小鼠, 基因敲除(Mice, Knockout);神经元(Neurons);Rett综合征(Rett Syndrome);时间因素(Time Factors);转录, 遗传(Transcription, Genetic);电压敏感染色成像(Voltage-Sensitive Dye Imaging)

DOI 10.1093/cercor/bhv078

PMID 25979088

发布时间 2017-05-22

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Cerebral cortex (New York, N.Y. : 1991)

Cerebral cortex (New York, N.Y.

2016年26卷6期

2517-2529页

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