换一批
换一批The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells.
第一作者：
Yan-Ning,Rui
第一单位：
a The Brown Foundation Institute of Molecular Medicine.
作者：
关键词
ACACA/B, acetyl-CoA carboxylase α/βACTB, actin, βATF4, activating transcription factor 4ATF6, activating transcription factor 6ATG7, autophagy-related 7BCL2, B-cell CLL/lymphoma 2BECN1, Beclin 1, autophagy-relatedBHMTBHMT, betaine-homocysteine S-methyltransferaseBaf A1, bafilomycin A1CTNNB1, catenin (cadherin-associated protein), β 1, 88kDaCvt, cytoplasm-to-vacuole-targetingDDIT3, DNA-damage-inducible transcript 3EBSS, Earle's Balanced Salt SolutionEIF2AK3, eukaryotic translation initiation factor 2-α, kinase 3EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1ER, endoplasmic reticulumERN1, endoplasmic reticulum to nucleus signaling 1GST, glutathionine S-transferaseGST-BHMT(FRAG), an autophagy-mediated cleavage product of the GST-BHMT reporterGST-BHMT, a fusion protein of glutathionine S-transferase N-terminal to betaine-homocysteine S-methyltransferaseHA, hemagglutininHSPA5, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)LSCS, linker-specific cleavage siteMAP1LC3, microtubule-associated protein 1 light chain 3MAP2K7, mitogen-activated protein kinase kinase 7MAPK8, mitogen-activated protein kinase 8MTORMTOR, mechanistic target of rapamycin (serine/threonine kinase)MTORC1, MTOR complex 1NBR1, neighbor of BRCA1 gene 1P4HB, prolyl 4-hydroxylase, β polypeptidePRKAA, protein kinase, AMP-activated, α catalytic subunitPRKAA/AMPKRHEB, Ras homolog enriched in brainRM, rich mediumRPS6KB1, ribosomal protein S6 kinase, 70kDa, polypeptide 1SQSTM1, sequestosome 1TSC1/2, tuberous sclerosis 1/2ULK1, unc-51 like autophagy activating kinase 1UPR, unfolded protein responseUPS, ubiquitin proteasome systemXBP1, X-box binding protein 1cargo receptors SQSTM1/p62 and NBR1proteasome inhibitionselective macroautophagy
主题词
AMP活化蛋白激酶类(AMP-Activated Protein Kinases);衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);自噬(Autophagy);甜菜碱-高半胱氨酸S-甲基转移酶(Betaine-Homocysteine S-Methyltransferase);内切核糖核酸酶类(Endoribonucleases);谷胱甘肽转移酶(Glutathione Transferase);HEK293细胞(HEK293 Cells);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);亮肽菌素类(Leupeptins);溶酶体(Lysosomes);膜蛋白质类(Membrane Proteins);丝裂原活化蛋白激酶8(Mitogen-Activated Protein Kinase 8);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);蛋白质结合(Protein Binding);蛋白质多聚化(Protein Multimerization);蛋白质加工, 转译后(Protein Processing, Post-Translational);蛋白质结构, 三级(Protein Structure, Tertiary);蛋白质类(Proteins);重组融合蛋白质类(Recombinant Fusion Proteins);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);泛素化(Ubiquitination)
DOI
10.1080/15548627.2015.1034402
PMID
25984893
发布时间
2021-12-03
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Autophagy
812-32页
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