首页> Free radical biology & medicine> Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease.

Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease.

导出 LinkOut

翻译打印收藏纠错

第一作者： M I,Nilsson

第一单位： Department of Pediatrics and Medicine, Neuromuscular Clinic, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

作者： M I,Nilsson ^[1] ; L G,MacNeil ^[1] ; Y,Kitaoka ^[1] ; R,Suri ^[1] ; S P,Young ^[2] ; J J,Kaczor ^[3] ; N J,Nates ^[1] ; M U,Ansari ^[1] ; T,Wong ^[1] ; M,Ahktar ^[1] ; L,Brandt ^[1] ; B P,Hettinga ^[1] ; M A,Tarnopolsky ^[4]

作者单位： Department of Pediatrics and Medicine, Neuromuscular Clinic, McMaster University, Hamilton, Ontario L8N 3Z5, Canada. ^[1] Department of Pediatrics, Division of Medical Genetics/Duke University Medical Center, Durham, NC, USA. ^[2] Department of Bioenergetics and Exercise Physiology, Medical University of Gdansk, Poland. ^[3] Department of Pediatrics and Medicine, Neuromuscular Clinic, McMaster University, Hamilton, Ontario L8N 3Z5, Canada. Electronic address: tarnopol@mcmaster.ca. ^[4]

关键词 Aging Autophagy Exocytosis Lipofuscin Lysosomal storage disorder Neurodegenerative disease