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IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like behavior by aging.

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第一作者： Chisato,Wakabayashi

第一单位： Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan; Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan. Electronic address: wakab@ncnp.go.jp.

作者： Chisato,Wakabayashi ^[1] ; Tadahiro,Numakawa ^[2] ; Haruki,Odaka ^[2] ; Yoshiko,Ooshima ^[2] ; Yuji,Kiyama ^[3] ; Toshiya,Manabe ^[3] ; Hiroshi,Kunugi ^[2] ; Yoichiro,Iwakura ^[4]

作者单位： Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan; Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan. Electronic address: wakab@ncnp.go.jp. ^[1] Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. ^[2] Division of Neuronal Network, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan. ^[3] Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan. ^[4]

关键词 Anxiety-like phenotype Elevated plus-maze test Glucocorticoid receptor Hippocampus IL-1 receptor antagonist