A new class of ghrelin O-acyltransferase inhibitors incorporating triazole-linked lipid mimetic groups.

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第一作者： Feifei,Zhao

第一单位： Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.

作者： Feifei,Zhao ^[1] ; Joseph E,Darling ^[2] ; Richard A,Gibbs ^[1] ; James L,Hougland ^[3]

作者单位： Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA. ^[1] Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA. ^[2] Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA. Electronic address: hougland@syr.edu. ^[3]

关键词 1,2,3-Triazole Ghrelin Ghrelin O-acyltransferase Peptidomimetic Serine acylation

主题词酰基转移酶类(Acyltransferases);酶抑制剂(Enzyme Inhibitors);人类(Humans);蛋白质结合(Protein Binding);蛋白质亚型(Protein Isoforms);构效关系(Structure-Activity Relationship);三唑类(Triazoles)

DOI 10.1016/j.bmcl.2015.05.009

PMID 26009163

发布时间 2021-08-30

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