首页> British journal of cancer> Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas.

Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas.

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第一作者： C,Yoon

第一单位： Department of Surgery, Memorial Sloan-Kettering Cancer Center, H-1209, 1275 York Avenue, New York, NY 10021, USA.

作者： C,Yoon ^[1] ; H-J,Lee ^[2] ; D J,Park ^[3] ; Y-J,Lee ^[2] ; W D,Tap ^[4] ; T S K,Eisinger-Mathason ^[5] ; C P,Hart ^[6] ; E,Choy ^[7] ; M C,Simon ^[8] ; S S,Yoon ^[1]

作者单位： Department of Surgery, Memorial Sloan-Kettering Cancer Center, H-1209, 1275 York Avenue, New York, NY 10021, USA. ^[1] 1] Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA [2] Division of Radiation Effects, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea. ^[2] 1] Department of Surgery, Memorial Sloan-Kettering Cancer Center, H-1209, 1275 York Avenue, New York, NY 10021, USA [2] Department of Surgery, Seoul National University Bundang Hospital, Sungnam, South Korea. ^[3] Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. ^[4] Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[5] Threshold Pharmaceuticals, South San Francisco, CA 94080, USA. ^[6] Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. ^[7] 1] Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA [2] Howard Hughes Medical Institute, Chevy Chase, MD, USA. ^[8]

医学主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);综合疗法(Combined Modality Therapy);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);硝基咪唑类(Nitroimidazoles);磷酸酰胺氮芥类(Phosphoramide Mustards);肉瘤(Sarcoma);血管内皮生长因子A(Vascular Endothelial Growth Factor A);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1038/bjc.2015.186

PMID 26010414

发布时间 2018-11-13

基金项目

R01 CA158301/CA/NCI NIH HHS/United States R21 CA117128/CA/NCI NIH HHS/United States 1R01 CA158301-01/CA/NCI NIH HHS/United States 1R21 CA117128-02/CA/NCI NIH HHS/United States

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