A generic high-throughput assay to detect aquaporin functional mutants: Potential application to discovery of aquaporin inhibitors.

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作者： Janet,To ^[1] ; Chiew Ying,Yeo ^[1] ; Cin Huang,Soon ^[1] ; Jaume,Torres ^[2]

作者单位： School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551. ^[1] School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551. Electronic address: jtorres@ntu.edu.sg. ^[2]

关键词 Aquaporin Z Drug discovery Freeze–thawing Functional mutant selection Human aquaporin 1 Yeast

主题词水通道蛋白质1(Aquaporin 1);药物发现(Drug Discovery);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);突变(Mutation);表面等离激元(Surface Plasmon Resonance)

DOI 10.1016/j.bbagen.2015.05.019

PMID 26028295

发布时间 2016-11-26

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