Promoter hypermethylation of let-7a-3 is relevant to its down-expression in diabetic nephropathy by targeting UHRF1.

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作者： Rui,Peng ^[1] ; Handeng,Liu ^[2] ; Huimin,Peng ^[3] ; Ji,Zhou ^[4] ; He,Zha ^[4] ; Xin,Chen ^[5] ; Luyu,Zhang ^[3] ; Yan,Sun ^[4] ; Pin,Yin ^[4] ; Li,Wen ^[4] ; Tianhui,Wu ^[4] ; Zheng,Zhang ^[6]

作者单位： Department of Bioinformatics, Chongqing Medical University, No. 1, Medical College Road, Chongqing 400016, China; Molecular Medicine and Cancer Research Center, Chongqing Medical University, No. 1, Medical College Road, Chongqing 400016, China. ^[1] Department of Cell Biology and Medical Genetics, Chongqing Medical University, No. 1, Medical College Road, Chongqing 400016, China. ^[2] Molecular Medicine and Cancer Research Center, Chongqing Medical University, No. 1, Medical College Road, Chongqing 400016, China. ^[3] Molecular Medicine and Cancer Research Center, Chongqing Medical University, No. 1, Medical College Road, Chongqing 400016, China; Department of Cell Biology and Medical Genetics, Chongqing Medical University, No. 1, Medical College Road, Chongqing 400016, China. ^[4] Department of Endocrinology, The First Affiliated Hospital, Chongqing Medical University, No. 1, Youyi Road, Chongqing 400010, China. ^[5] Molecular Medicine and Cancer Research Center, Chongqing Medical University, No. 1, Medical College Road, Chongqing 400016, China; Department of Cell Biology and Medical Genetics, Chongqing Medical University, No. 1, Medical College Road, Chongqing 400016, China. Electronic address: zhangzheng92@163.com. ^[6]

关键词 Diabetic nephropathy Methylation MicroRNA