Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species.

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第一作者： Sheng-Xiong,Huang

第一单位： Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458;

作者： Sheng-Xiong,Huang ^[1] ; Bong-Sik,Yun ^[2] ; Ming,Ma ^[1] ; Hirak S,Basu ^[3] ; Dawn R,Church ^[3] ; Gudrun,Ingenhorst ^[2] ; Yong,Huang ^[2] ; Dong,Yang ^[1] ; Jeremy R,Lohman ^[1] ; Gong-Li,Tang ^[2] ; Jianhua,Ju ^[2] ; Tao,Liu ^[2] ; George,Wilding ^[4] ; Ben,Shen ^[5]

作者单位： Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458; ^[1] Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI 53705; ^[2] University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705; ^[3] University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705; ^[4] Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458; Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI 53705; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458; Natural Products Library Initiative, The Scripps Research Institute, Jupiter, FL 33458 shenb@scripps.edu. ^[5]

关键词 cancer targeting drug discovery natural product pathway engineering sulfur metabolism