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Single-molecule analysis reveals widespread structural variation in multiple myeloma.

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第一作者： Aditya,Gupta

第一单位： Biophysics Graduate Program, University of Wisconsin-Madison, Madison, WI 53706; Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics and Biotechnology Center, University of Wisconsin-Madison, Madison, WI 53706; University of Wisconsin Carbone Cancer Center, Madison, WI 53705;

作者： Aditya,Gupta ^[1] ; Michael,Place ^[2] ; Steven,Goldstein ^[2] ; Deepayan,Sarkar ^[3] ; Shiguo,Zhou ^[2] ; Konstantinos,Potamousis ^[2] ; Jaehyup,Kim ^[4] ; Claire,Flanagan ^[4] ; Yang,Li ^[5] ; Michael A,Newton ^[6] ; Natalie S,Callander ^[4] ; Peiman,Hematti ^[4] ; Emery H,Bresnick ^[7] ; Jian,Ma ^[5] ; Fotis,Asimakopoulos ^[4] ; David C,Schwartz ^[8]

作者单位： Biophysics Graduate Program, University of Wisconsin-Madison, Madison, WI 53706; Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics and Biotechnology Center, University of Wisconsin-Madison, Madison, WI 53706; University of Wisconsin Carbone Cancer Center, Madison, WI 53705; ^[1] Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics and Biotechnology Center, University of Wisconsin-Madison, Madison, WI 53706; University of Wisconsin Carbone Cancer Center, Madison, WI 53705; ^[2] Indian Statistical Institute, New Delhi 110016, India; ^[3] University of Wisconsin Carbone Cancer Center, Madison, WI 53705; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705; ^[4] Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; ^[5] University of Wisconsin Carbone Cancer Center, Madison, WI 53705; Department of Statistics, University of Wisconsin-Madison, Madison, WI 53706; ^[6] University of Wisconsin Carbone Cancer Center, Madison, WI 53705; Department of Cell and Regenerative Biology, University of Wisconsin-Madison Blood Research Program, Madison, WI 53705. ^[7] Biophysics Graduate Program, University of Wisconsin-Madison, Madison, WI 53706; Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics and Biotechnology Center, University of Wisconsin-Madison, Madison, WI 53706; University of Wisconsin Carbone Cancer Center, Madison, WI 53705; dcschwartz@wisc.edu. ^[8]

关键词 DNA sequencing copy number multiple myeloma optical mapping structural variation

医学主题词 DNA(DNA);DNA拷贝数变异(DNA Copy Number Variations);人类(Humans);杂合子丢失(Loss of Heterozygosity);多发性骨髓瘤(Multiple Myeloma);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1073/pnas.1418577112

PMID 26056298

发布时间 2019-06-10

基金项目

R01 HG000225/HG/NHGRI NIH HHS/United States R33 CA111933/CA/NCI NIH HHS/United States R33 CA182360/CA/NCI NIH HHS/United States R01HG000225/HG/NHGRI NIH HHS/United States

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