Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.-论文-万方医学网

作者： Michael,Seimetz ^[1] ; Nirmal,Parajuli ^[1] ; Alexandra,Pichl ^[1] ; Mariola,Bednorz ^[1] ; Hossein Ardeschir,Ghofrani ^[1] ; Ralph Theo,Schermuly ^[1] ; Werner,Seeger ^[1] ; Friedrich,Grimminger ^[1] ; Norbert,Weissmann ^[1]

作者单位： Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany. ^[1]

主题词动物(Animals);苯甲酰胺类(Benzamides);环AMP(Cyclic AMP);环GMP(Cyclic GMP);环核苷酸磷酸二酯酶类, 4型(Cyclic Nucleotide Phosphodiesterases, Type 4);环核苷酸磷酸二酯酶类, 5型(Cyclic Nucleotide Phosphodiesterases, Type 5);疾病模型, 动物(Disease Models, Animal);高血压, 肺性(Hypertension, Pulmonary);肺(Lung);肺顺应性(Lung Compliance);巨噬细胞, 肺泡(Macrophages, Alveolar);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);磷酸二酯酶4抑制剂(Phosphodiesterase 4 Inhibitors);磷酸二酯酶5抑制剂(Phosphodiesterase 5 Inhibitors);肺疾病, 慢性阻塞性(Pulmonary Disease, Chronic Obstructive);肺气肿(Pulmonary Emphysema);吡啶类(Pyridines);烟(Smoke);吸烟(Smoking)

DOI 10.1371/journal.pone.0129327

PMID 26058042

发布时间 2018-11-13

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Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.

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Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.

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