Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial.-论文-万方医学网

第一作者： Graham,Devereux

第一单位： Respiratory Medicine, Chest Clinic C, Aberdeen Royal Infirmary, University of Aberdeen, Aberdeen, AB25 2ZN, UK. g.devereux@abdn.ac.uk.

作者： Graham,Devereux ^[1] ; Seonaidh,Cotton ^[2] ; Peter,Barnes ^[3] ; Andrew,Briggs ^[4] ; Graham,Burns ^[5] ; Rekha,Chaudhuri ^[6] ; Henry,Chrystyn ^[7] ; Lisa,Davies ^[8] ; Anthony,De Soyza ^[9] ; Shona,Fielding ^[10] ; Simon,Gompertz ^[11] ; John,Haughney ^[12] ; Amanda J,Lee ^[13] ; Kirsty,McCormack ^[14] ; Gladys,McPherson ^[15] ; Alyn,Morice ^[16] ; John,Norrie ^[17] ; Anita,Sullivan ^[18] ; Andrew,Wilson ^[19] ; David,Price ^[20]

作者单位： Respiratory Medicine, Chest Clinic C, Aberdeen Royal Infirmary, University of Aberdeen, Aberdeen, AB25 2ZN, UK. g.devereux@abdn.ac.uk. ^[1] Centre for Healthcare Randomised Trials (CHaRT), University of Aberdeen, Aberdeen, AB25 2ZN, UK. s.c.cotton@abdn.ac.uk. ^[2] Imperial College, National Heart & Lung Institute, Dovehouse Street, London, SW3 6LY, UK. p.j.barnes@imperial.ac.uk. ^[3] Institute of Health & Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow, G12 8RZ, UK. andrew.briggs@glasgow.ac.uk. ^[4] Department of Respiratory Medicine, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK. graham.burns@nuth.nhs.uk. ^[5] Gartnavel General Hospital, University of Glasgow, Glasgow, G12 0YN, UK. rekha.chaudhuri@ggc.scot.nhs.uk. ^[6] Division of Pharmacy & Pharmaceutical Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK. h.chrystyn@hud.ac.uk. ^[7] Aintree Chest Centre, University Hospital Aintree, Liverpool, L9 7AL, UK. lisa.davies@aintree.nhs.uk. ^[8] Medical School, University of Newcastle, Newcastle Upon Tyne, NE2 4HH, UK. anthony.de-soyza@newcastle.ac.uk. ^[9] Medical Statistics Team, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK. s.fielding@abdn.ac.uk. ^[10] Queen Elizabeth Hospital Birmingham, Birmingham, B15 2WB, UK. simon.gompertz@uhb.nhs.uk. ^[11] Centre of Academic Primary Care, University of Aberdeen, Aberdeen, AB25 2ZD, UK. j.haughney@abdn.ac.uk. ^[12] Medical Statistics Team, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK. a.j.lee@abdn.ac.uk. ^[13] Centre for Healthcare Randomised Trials (CHaRT), University of Aberdeen, Aberdeen, AB25 2ZN, UK. k.mccormack@abdn.ac.uk. ^[14] Centre for Healthcare Randomised Trials (CHaRT), University of Aberdeen, Aberdeen, AB25 2ZN, UK. g.mcpherson@abdn.ac.uk. ^[15] Cardiovascular and Respiratory Studies, Castle Hill Hospital, Hull, HU16 5JQ, UK. a.h.morice@hull.ac.uk. ^[16] Centre for Healthcare Randomised Trials (CHaRT), University of Aberdeen, Aberdeen, AB25 2ZN, UK. j.norrie@abdn.ac.uk. ^[17] Queen Elizabeth Hospital Birmingham, Birmingham, B15 2WB, UK. anita.sullivan@uhb.nhs.uk. ^[18] Department of Medicine, Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK. a.m.wilson@uea.ac.uk. ^[19] Centre of Academic Primary Care, University of Aberdeen, Aberdeen, AB25 2ZD, UK. david@respiratoryresearch.org. ^[20]

医学主题词投药, 吸入(Administration, Inhalation);投药, 口服(Administration, Oral);肾上腺皮质激素类(Adrenal Cortex Hormones);成年人(Adult);抗菌药(Anti-Bacterial Agents);支气管扩张药(Bronchodilator Agents);临床方案(Clinical Protocols);费用效益分析(Cost-Benefit Analysis);疾病恶化(Disease Progression);双盲法(Double-Blind Method);药费支出(Drug Costs);药物疗法, 联合(Drug Therapy, Combination);女(雌)性(Female);用力呼气量(Forced Expiratory Volume);人类(Humans);肺(Lung);男(雄)性(Male);肺疾病, 慢性阻塞性(Pulmonary Disease, Chronic Obstructive);研究设计(Research Design);茶碱(Theophylline);时间因素(Time Factors);治疗结果(Treatment Outcome);肺活量(Vital Capacity)

DOI 10.1186/s13063-015-0782-2

PMID 26058585

发布时间 2025-05-29

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Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial.

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Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial.

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