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Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.

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第一作者： Robert A,Whittington

第一单位： Department of Anesthesiology, Columbia University, College of Physicians and Surgeons, New York, NY, USA. Electronic address: raw9@cumc.columbia.edu.

作者： Robert A,Whittington ^[1] ; László,Virág ^[2] ; Maud,Gratuze ^[3] ; Franck R,Petry ^[3] ; Anastasia,Noël ^[3] ; Isabelle,Poitras ^[3] ; Geoffrey,Truchetti ^[3] ; François,Marcouiller ^[3] ; Marie-Amélie,Papon ^[3] ; Noura,El Khoury ^[3] ; Kevin,Wong ^[2] ; Alexis,Bretteville ^[3] ; Françoise,Morin ^[4] ; Emmanuel,Planel ^[5]

作者单位： Department of Anesthesiology, Columbia University, College of Physicians and Surgeons, New York, NY, USA. Electronic address: raw9@cumc.columbia.edu. ^[1] Department of Anesthesiology, Columbia University, College of Physicians and Surgeons, New York, NY, USA. ^[2] Département de Psychiatrie et Neurosciences, Faculté de Médecine, Université Laval, Québec, Québec, Canada. ^[3] Neurosciences, CHUL, CRCHU, Québec, Québec, Canada. ^[4] Département de Psychiatrie et Neurosciences, Faculté de Médecine, Université Laval, Québec, Québec, Canada; Neurosciences, CHUL, CRCHU, Québec, Québec, Canada. ^[5]

关键词 Alzheimer's disease Anesthesia Cells Dexmedetomidine Mouse Tau