Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.

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第一作者： Chunxia,Zhao

第一单位： Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, China.;Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

作者： Chunxia,Zhao ^[1] ; Lijie,Wang ^[1] ; Xiue,Ma ^[1] ; Weidong,Zhu ^[2] ; Lei,Yao ^[3] ; Yingyu,Cui ^[4] ; Yi,Liu ^[5] ; Jun,Li ^[5] ; Xingqun,Liang ^[2] ; Yunfu,Sun ^[2] ; Li,Li ^[4] ; Yi-Han,Chen ^[6]

作者单位： Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, China.;Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. ^[1] Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, China.;Research Center for Translational Medicine, Tongji University School of Medicine, Shanghai, China.;Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China. ^[2] Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, China.;Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.;Research Center for Translational Medicine, Tongji University School of Medicine, Shanghai, China. ^[3] Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, China.;Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China.;Institute of Medical Genetics, Tongji University, Shanghai, China. ^[4] Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, China.;Research Center for Translational Medicine, Tongji University School of Medicine, Shanghai, China.;Institute of Medical Genetics, Tongji University, Shanghai, China. ^[5] Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, China.;Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.;Research Center for Translational Medicine, Tongji University School of Medicine, Shanghai, China.;Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China.;Institute of Medical Genetics, Tongji University, Shanghai, China. ^[6]

关键词 Nav1.5 channel UBR cardiomyocyte degradation proteasome ubiquitin