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首页> Toxicology> Nonylphenol affects myocardial contractility and L-type Ca(2+) channel currents in a non-monotonic manner via G protein-coupled receptor 30.

Nonylphenol affects myocardial contractility and L-type Ca(2+) channel currents in a non-monotonic manner via G protein-coupled receptor 30.

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作者： Qinghua,Gao ^[1] ; Shuyuan,Liu ^[2] ; Feng,Guo ^[2] ; Shuice,Liu ^[2] ; Xiangchen,Yu ^[2] ; Huiyuan,Hu ^[2] ; Xuefei,Sun ^[2] ; Liying,Hao ^[3] ; Tong,Zhu ^[4]

作者单位： Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China; Department of Physiology, College of Basic Medical Sciences, China Medical University, Shenyang 110122, China. ^[1] Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China. ^[2] Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China. Electronic address: lyhao@mail.cmu.edu.cn. ^[3] Laboratory of Environmental Biology and Engineering, Northeastern University, Shenyang 110004, China. Electronic address: tongzhu@mail.neu.edu.cn. ^[4]

关键词 Cardiac myocytes GPR30 L-type Ca(2+) current Nonylphenol Xenoestrogen

主题词动物(Animals);钙通道, L型(Calcium Channels, L-Type);钙信号(Calcium Signaling);剂量效应关系, 药物(Dose-Response Relationship, Drug);雌激素类(Estrogens);女(雌)性(Female);豚鼠(Guinea Pigs);动力学(Kinetics);膜电位(Membrane Potentials);心肌收缩(Myocardial Contraction);肌细胞, 心脏(Myocytes, Cardiac);灌流(Perfusion);酚类(Phenols);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);信号传导(Signal Transduction)

DOI 10.1016/j.tox.2015.06.004

PMID 26070386

发布时间 2022-04-08

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Toxicology

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