New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure.

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作者： Claudia,Barthel ^[1] ; Dietlind,Sorger ^[2] ; Winnie,Deuther-Conrad ^[1] ; Matthias,Scheunemann ^[1] ; Stephanie,Schweiger ^[1] ; Petra,Jäckel ^[1] ; Ali,Roghani ^[3] ; Jörg,Steinbach ^[1] ; Gerrit,Schüürmann ^[4] ; Osama,Sabri ^[2] ; Peter,Brust ^[1] ; Barbara,Wenzel ^[5]

作者单位： Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Germany. ^[1] Department of Nuclear Medicine, University of Leipzig, Germany. ^[2] Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, USA. ^[3] UFZ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research, Leipzig, Germany. ^[4] Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, Germany. Electronic address: b.wenzel@hzdr.de. ^[5]

关键词 PET Sigma receptors VAChT Vesamicol

主题词动物(Animals);脑(Brain);剂量效应关系, 药物(Dose-Response Relationship, Drug);女(雌)性(Female);分子显像(Molecular Imaging);分子结构(Molecular Structure);PC12细胞(PC12 Cells);哌啶类(Piperidines);正电子发射断层显像术(Positron-Emission Tomography);放射配体测定(Radioligand Assay);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);构效关系(Structure-Activity Relationship);囊泡乙酰胆碱转运蛋白质类(Vesicular Acetylcholine Transport Proteins)

DOI 10.1016/j.ejmech.2015.05.033

PMID 26071858

发布时间 2015-07-08

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European journal of medicinal chemistry

2015年100卷

50-67页

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New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure.

European journal of medicinal chemistry

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European journal of medicinal chemistry

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New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

检索历史清除