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Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum.

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第一作者： Stefan,Schorr

第一单位： From the Departments of Medical Biochemistry and Molecular Biology and.

作者： Stefan,Schorr ^[1] ; Marie-Christine,Klein ^[1] ; Igor,Gamayun ^[2] ; Armin,Melnyk ^[1] ; Martin,Jung ^[1] ; Nico,Schäuble ^[1] ; Qian,Wang ^[3] ; Birgit,Hemmis ^[4] ; Florian,Bochen ^[1] ; Markus,Greiner ^[1] ; Pavel,Lampel ^[1] ; Sabine Katharina,Urban ^[1] ; Sarah,Hassdenteufel ^[1] ; Johanna,Dudek ^[1] ; Xing-Zhen,Chen ^[3] ; Richard,Wagner ^[4] ; Adolfo,Cavalié ^[2] ; Richard,Zimmermann ^[5]

作者单位： From the Departments of Medical Biochemistry and Molecular Biology and. ^[1] Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421 Homburg, Germany. ^[2] the Department of Physiology, University of Alberta, Edmonton T6G 2H7, Canada, and. ^[3] the Division of Biophysics, Universität Osnabrück, FB Biologie/Chemie, 49076 Osnabrück, Germany. ^[4] From the Departments of Medical Biochemistry and Molecular Biology and richard.zimmermann@uks.eu. ^[5]

关键词 BiP ER calcium leakage Sec61 complex gating calcium imaging cellular calcium homeostasis chaperone diabetes endoplasmic reticulum (ER)protein translocation