Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.

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作者： Chutikarn,Butkinaree ^[1] ; Maryssa,Canuel ^[1] ; Rachid,Essalmani ^[1] ; Steve,Poirier ^[2] ; Suzanne,Benjannet ^[1] ; Marie-Claude,Asselin ^[1] ; Anna,Roubtsova ^[1] ; Josée,Hamelin ^[1] ; Jadwiga,Marcinkiewicz ^[1] ; Ann,Chamberland ^[1] ; Johann,Guillemot ^[1] ; Gaétan,Mayer ^[2] ; Sangram S,Sisodia ^[3] ; Yves,Jacob ^[4] ; Annik,Prat ^[1] ; Nabil G,Seidah ^[5]

作者单位： From the Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec H2W 1R7, Canada. ^[1] the Laboratory of Molecular Cell Biology, Montreal Heart Institute, 5000 Bélanger, Montréal, Quebec H1T 1C8, Canada. ^[2] the Department of Neurobiology, University of Chicago, Chicago, Illinois 60637. ^[3] the Département de Virologie, Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN, F-75015 Paris, France, the CNRS, URA3015, F-75015 Paris, France, and the Université Paris Diderot, Sorbonne Paris Cité, Unité de Génétique Moléculaire des Virus à ARN, F-75015 Paris, France. ^[4] From the Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec H2W 1R7, Canada, seidahn@ircm.qc.ca. ^[5]

关键词 APLP2 Sortilin (SORT1)cardiovascular disease dyslipidemia lipoprotein metabolism low-density lipoprotein (LDL)low-density lipoprotein receptor (LDLR) degradation proprotein convertase subtilisin/kexin type 9 (PCSK9)