Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule.

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作者： Vojtech,Vyklicky ^[1] ; Barbora,Krausova ^[1] ; Jiri,Cerny ^[1] ; Ales,Balik ^[1] ; Martin,Zapotocky ^[1] ; Marian,Novotny ^[2] ; Katarina,Lichnerova ^[1] ; Tereza,Smejkalova ^[1] ; Martina,Kaniakova ^[1] ; Miloslav,Korinek ^[1] ; Milos,Petrovic ^[3] ; Petr,Kacer ^[4] ; Martin,Horak ^[1] ; Hana,Chodounska ^[5] ; Ladislav,Vyklicky ^[1]

作者单位： Institute of Physiology CAS, Videnska 1083, 142 20 Prague 4, Czech Republic. ^[1] Charles University in Prague, Faculty of Science, Albertov 6, 128 43 Prague 2, Czech Republic. ^[2] 1] Institute of Physiology CAS, Videnska 1083, 142 20 Prague 4, Czech Republic [2] School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, UK [3] Institute of Medical Physiology, School of Medicine, University of Belgrade, Visegradska 26/II, 11000 Beograd, Srbija. ^[3] Institute of Chemical Technology-Prague, Technicka 5, 166 28 Prague, Czech Republic. ^[4] Institute of Organic Chemistry and Biochemistry CAS, Flemingovo nam. 2, 166 10 Prague 2, Czech Republic. ^[5]

主题词氨基酸特征结构(Amino Acid Motifs);人类(Humans);突变(Mutation);孕烷诺龙(Pregnanolone);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);前庭, 迷路(Vestibule, Labyrinth)

DOI 10.1038/srep10935

PMID 26086919

发布时间 2024-03-23

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Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule.

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Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule.

Scientific reports

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