Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.-论文-万方医学网

作者： Seo Hee,Nam ^[1] ; Doyeun,Kim ^[2] ; Mi-Sook,Lee ^[2] ; Doohyung,Lee ^[2] ; Tae Kyoung,Kwak ^[2] ; Minkyung,Kang ^[2] ; Jihye,Ryu ^[3] ; Hye-Jin,Kim ^[2] ; Haeng Eun,Song ^[2] ; Jungeun,Choi ^[2] ; Gyu-Ho,Lee ^[1] ; Sang-Yeob,Kim ^[2] ; Song Hwa,Park ^[4] ; Dae Gyu,Kim ^[2] ; Nam Hoon,Kwon ^[2] ; Tai Young,Kim ^[2] ; Jean Paul,Thiery ^[2] ; Sunghoon,Kim ^[5] ; Jung Weon,Lee ^[6]

作者单位： Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul, Republic of Korea. ^[1] Department of Pharmacy, Medicinal Bioconvergence Research Center, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea. ^[2] Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea. ^[3] Department of Medicine, University of Ulsan, College of Medicine, Seoul, Republic of Korea. ^[4] Cancer Science Institute, National University of Singapore, Singapore. ^[5] Institute of Molecular and Cell Biology, A*STAR, Singapore. ^[6] Department of Biochemistry, School of Medicine, National University of Singapore, Singapore. ^[7]

主题词动物(Animals);钙黏着糖蛋白类(Cadherins);细胞黏附(Cell Adhesion);细胞系, 肿瘤(Cell Line, Tumor);胶原Ⅰ型(Collagen Type I);结肠肿瘤(Colonic Neoplasms);胞质溶胶(Cytosol);细胞外基质(Extracellular Matrix);女(雌)性(Female);荧光共振能量转移(Fluorescence Resonance Energy Transfer);荧光抗体技术, 间接(Fluorescent Antibody Technique, Indirect);HCT116细胞(HCT116 Cells);人类(Humans);赖氨酸tRNA连接酶(Lysine-tRNA Ligase);小鼠(Mice);肿瘤转移(Neoplasm Metastasis);桩蛋白(Paxillin);磷酰化(Phosphorylation);蛋白质生物合成(Protein Biosynthesis);信号传导(Signal Transduction)

DOI 10.18632/oncotarget.4130

PMID 26091349

发布时间 2018-11-13

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Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.

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Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.

Oncotarget

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Oncotarget

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