Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha.
作者:
主题词
酰胺基水解酶类(Amidohydrolases);精氨酸(Arginine);钙(Calcium);细胞低氧(Cell Hypoxia);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);剂量效应关系, 药物(Dose-Response Relationship, Drug);内皮细胞(Endothelial Cells);人类(Humans);高血压, 肺性(Hypertension, Pulmonary);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);炎症介导素类(Inflammation Mediators);胞间黏附分子1(Intercellular Adhesion Molecule-1);肌, 平滑, 血管(Muscle, Smooth, Vascular);肌细胞, 平滑肌(Myocytes, Smooth Muscle);一氧化氮(Nitric Oxide);一氧化氮合酶Ⅲ型(Nitric Oxide Synthase Type III);肺动脉(Pulmonary Artery);STAT3转录因子(STAT3 Transcription Factor);信号传导(Signal Transduction)
DOI
10.1016/j.vph.2015.06.005
PMID
26091577
发布时间
2016-11-25
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Vascular pharmacology
138-48页
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