Current status of the development of Ras inhibitors.

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作者： Fumi,Shima ^[1] ; Shigeyuki,Matsumoto ^[2] ; Yoko,Yoshikawa ^[2] ; Takashi,Kawamura ^[2] ; Masayuki,Isa ^[2] ; Tohru,Kataoka ^[3]

作者单位： Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan sfumi@med.kobe-u.ac.jp. ^[1] Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. ^[2] Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan kataoka@people.kobe-u.ac.jp. ^[3]

关键词 NMR Ras X-ray crystallography anti-cancer drugs drug design structure-based

主题词动物(Animals);酶抑制剂(Enzyme Inhibitors);人类(Humans);模型, 分子(Models, Molecular);蛋白质结合(Protein Binding);信号传导(Signal Transduction);ras蛋白质类(ras Proteins)

DOI 10.1093/jb/mvv060

PMID 26100833

发布时间 2015-07-29

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准确一般字义偏差语意偏离译文作用小提交