换一批Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.
第一作者：
Jennifer E,Huffman
第一单位：
Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; The Framingham Heart Study, Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, Framingham, MA; The Framingham Heart Study, Framingham, MA, and the Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
作者：
Jennifer E,Huffman [1]
;
Paul S,de Vries [2]
;
Alanna C,Morrison [3]
;
Maria,Sabater-Lleal [4]
;
Tim,Kacprowski [5]
;
Paul L,Auer [6]
;
Jennifer A,Brody [7]
;
Daniel I,Chasman [8]
;
Ming-Huei,Chen [9]
;
Xiuqing,Guo [10]
;
Li-An,Lin [11]
;
Riccardo E,Marioni [12]
;
Martina,Müller-Nurasyid [13]
;
Lisa R,Yanek [14]
;
Nathan,Pankratz [15]
;
Megan L,Grove [3]
;
Moniek P M,de Maat [16]
;
Mary,Cushman [17]
;
Kerri L,Wiggins [7]
;
Lihong,Qi [18]
;
Bengt,Sennblad [19]
;
Sarah E,Harris [20]
;
Ozren,Polasek [21]
;
Helene,Riess [22]
;
Fernando,Rivadeneira [23]
;
Lynda M,Rose [24]
;
Anuj,Goel [25]
;
Kent D,Taylor [10]
;
Alexander,Teumer [26]
;
André G,Uitterlinden [23]
;
Dhananjay,Vaidya [27]
;
Jie,Yao [28]
;
Weihong,Tang [29]
;
Daniel,Levy [30]
;
Melanie,Waldenberger [31]
;
Diane M,Becker [32]
;
Aaron R,Folsom [29]
;
Franco,Giulianini [24]
;
Andreas,Greinacher [33]
;
Albert,Hofman [2]
;
Chiang-Ching,Huang [6]
;
Charles,Kooperberg [34]
;
Angela,Silveira [4]
;
John M,Starr [35]
;
Konstantin,Strauch [36]
;
Rona J,Strawbridge [4]
;
Alan F,Wright [37]
;
Barbara,McKnight [38]
;
Oscar H,Franco [2]
;
Neil,Zakai [17]
;
Rasika A,Mathias [39]
;
Bruce M,Psaty [40]
;
Paul M,Ridker [8]
;
Geoffrey H,Tofler [41]
;
Uwe,Völker [5]
;
Hugh,Watkins [25]
;
Myriam,Fornage [11]
;
Anders,Hamsten [4]
;
Ian J,Deary [42]
;
Eric,Boerwinkle [43]
;
Wolfgang,Koenig [44]
;
Jerome I,Rotter [10]
;
Caroline,Hayward [37]
;
Abbas,Dehghan [2]
;
Alex P,Reiner [45]
;
Christopher J,O'Donnell [46]
;
Nicholas L,Smith [47]
作者单位：
Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; The Framingham Heart Study, Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, Framingham, MA; The Framingham Heart Study, Framingham, MA, and the Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
[1]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;
[2]
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX;
[3]
Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden;
[4]
Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany;
[5]
Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI;
[6]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA;
[7]
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA;
[8]
Department of Neurology, Boston University School of Medicine, Boston, MA;
[9]
The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, and Department of Pediatrics, Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA;
[10]
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX;
[11]
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia;
[12]
Institute of Genetic Epidemiology, Helmholtz Centre Munich-German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany; German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany;
[13]
GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD;
[14]
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN;
[15]
Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;
[16]
Departments of Medicine and Pathology, University of Vermont, Colchester, VT;
[17]
University of California at Davis, Davis, CA;
[18]
Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden; Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden;
[19]
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom;
[20]
Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia;
[21]
Institute of Epidemiology II, Helmholtz Centre Munich-German Research Center for Environmental Health, Neuherberg, Germany; Department of Internal Medicine II-Cardiology, University of Ulm Medical School, Ulm, Germany;
[22]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands;
[23]
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA;
[24]
Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom;
[25]
Study of Health in Pomerania/ Clinical and Epidemiological Research Department, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany;
[26]
GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD;
[27]
The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, and.
[28]
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN;
[29]
The Framingham Heart Study, Framingham, MA, and the Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
[30]
German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany; Institute of Epidemiology II, Helmholtz Centre Munich-German Research Center for Environmental Health, Neuherberg, Germany; Research Unit of Molecular Epidemiology, Helmholtz Centre Munich-German Research Center for Environmental Health, Neuherberg, Germany;
[31]
GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD;
[32]
Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany;
[33]
Fred Hutchinson Cancer Research Center, Seattle, WA;
[34]
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Alzheimer Scotland Dementia Research Centre, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom;
[35]
Institute of Genetic Epidemiology, Helmholtz Centre Munich-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany;
[36]
Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom;
[37]
Department of Biostatistics, University of Washington, Seattle, WA;
[38]
GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD;
[39]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA; Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA; Group Health Research Institute, Group Health Cooperative, Seattle, WA;
[40]
Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia;
[41]
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom;
[42]
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX;
[43]
Department of Internal Medicine II-Cardiology, University of Ulm Medical School, Ulm, Germany; German Heart Centre Munich, Munich Technical University, Munich, Germany; and.
[44]
Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Epidemiology, and.
[45]
The Framingham Heart Study, Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, Framingham, MA;
[46]
Department of Epidemiology, and Group Health Research Institute, Group Health Cooperative, Seattle, WA; Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development, Seattle, WA.
[47]
医学主题词
队列研究(Cohort Studies);因子Ⅶ(Factor VII);因子Ⅷ(Factor VIII);纤维蛋白原(Fibrinogen);基因频率(Gene Frequency);遗传关联研究(Genetic Association Studies);遗传变异(Genetic Variation);人类(Humans);神经组织蛋白质类(Nerve Tissue Proteins);多态性, 单核苷酸(Polymorphism, Single Nucleotide);钾通道(Potassium Channels);von Willebrand因子(von Willebrand Factor)
DOI
10.1182/blood-2015-02-624551
PMID
26105150
发布时间
2025-05-29
基金项目
R01 HL120393/HL/NHLBI NIH HHS/United States
P30 CA015704/CA/NCI NIH HHS/United States
R01 HL059367/HL/NHLBI NIH HHS/United States
UL1 TR000124/TR/NCATS NIH HHS/United States
MR/K026992/1/MRC_/Medical Research Council/United Kingdom
R01 HL105756/HL/NHLBI NIH HHS/United States
P30 DK063491/DK/NIDDK NIH HHS/United States
BB/F019394/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
ETM/55/CSO_/Chief Scientist Office/United Kingdom
CZB/4/505/CSO_/Chief Scientist Office/United Kingdom
R01 HL112064/HL/NHLBI NIH HHS/United States
MC_PC_U127561128/MRC_/Medical Research Council/United Kingdom
UM1 CA182913/CA/NCI NIH HHS/United States
S10 OD020069/OD/NIH HHS/United States
G0700704/MRC_/Medical Research Council/United Kingdom
- 浏览42
Blood
Blood
e19-29页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
