Differential sensitivity of lipegfilgrastim and pegfilgrastim to neutrophil elastase correlates with differences in clinical pharmacokinetic profile.

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作者： Afsaneh,Abdolzade-Bavil ^[1] ; Aaron,von Kerczek ^[2] ; Bridget A,Cooksey ^[2] ; Thomas,Kaufman ^[2] ; Philip A,Krasney ^[2] ; Laurie,Pukac ^[2] ; Matthias,Görlach ^[3] ; Andreas,Lammerich ^[1] ; Christian,Scheckermann ^[4] ; Hermann,Allgaier ^[4] ; Wenyan David,Shen ^[5] ; Patrick M,Liu ^[2]

作者单位： Merckle GmbH, Ulm, Germany. ^[1] Teva Biopharmaceuticals USA, Inc., Rockville, MD, USA. ^[2] Leibniz Institute for Age Research, -, Fritz Lipmann Institute, Jena, Germany. ^[3] Merckle Biotec GmbH, Ulm, Germany. ^[4] Teva Pharmaceuticals, Inc., North Wales, PA, USA. ^[5]

关键词 granulocyte colony-stimulating factor granulocyte colony-stimulating factor receptor lipegfilgrastim long-acting G-CSF neutrophil elastase

主题词非格司亭(Filgrastim);粒细胞集落刺激因子(Granulocyte Colony-Stimulating Factor);人类(Humans);白细胞弹性蛋白酶(Leukocyte Elastase);中性白细胞(Neutrophils);聚乙烯二醇类(Polyethylene Glycols);重组蛋白质类(Recombinant Proteins)

DOI 10.1002/jcph.578

PMID 26105553

发布时间 2018-12-02

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