Isoprenoid Biosynthesis in Pathogenic Bacteria: Nuclear Resonance Vibrational Spectroscopy Provides Insight into the Unusual [4Fe-4S] Cluster of the E. coli LytB/IspH Protein.

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作者： Isabelle,Faus ^[1] ; Annegret,Reinhard ^[1] ; Sergej,Rackwitz ^[1] ; Juliusz A,Wolny ^[1] ; Kai,Schlage ^[2] ; Hans-Christian,Wille ^[2] ; Aleksandr,Chumakov ^[3] ; Sergiy,Krasutsky ^[4] ; Philippe,Chaignon ^[5] ; C Dale,Poulter ^[4] ; Myriam,Seemann ^[6] ; Volker,Schünemann ^[7]

作者单位： Fachbereich Physik, TU Kaiserslautern, Erwin-Schrödinger-Strasse 46, 67653 Kaiserslautern (Germany). ^[1] P01, Petra III, DESY, Notkestrasse 85, D-22607 Hamburg (Germany). ^[2] ESRF - The European Synchrotron, CS40220, 38043 Grenoble Cedex 9 (France). ^[3] Department of Chemistry, University of Utah, 315 South 1400 East RM 2020, Salt Lake City, UT 84112 (USA). ^[4] Université de Strasbourg, UMR 7177 CNRS, Institut Le Bel, 4 rue Blaise Pascal, CS 90032, 67081 Strasbourg Cedex (France). ^[5] Université de Strasbourg, UMR 7177 CNRS, Institut Le Bel, 4 rue Blaise Pascal, CS 90032, 67081 Strasbourg Cedex (France). mseemann@unistra.fr. ^[6] Fachbereich Physik, TU Kaiserslautern, Erwin-Schrödinger-Strasse 46, 67653 Kaiserslautern (Germany). schuene@physik.uni-kl.de. ^[7]

关键词 LytB(IspH)inhibitors metalloenzymes methylerythritol phosphate pathway nuclear resonance vibrational spectroscopy