Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease.
作者:
主题词
老年人(Aged);动物(Animals);轴突(Axons);脑(Brain);大脑皮质(Cerebral Cortex);女(雌)性(Female);基因表达(Gene Expression);基因, 报告(Genes, Reporter);人类(Humans);杭廷顿病(Huntington Disease);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);显微镜检查, 共焦(Microscopy, Confocal);中年人(Middle Aged);神经变性(Nerve Degeneration);神经元(Neurons);血清素质膜转运蛋白质类(Serotonin Plasma Membrane Transport Proteins);疾病严重程度指数(Severity of Illness Index)
DOI
10.1093/hmg/ddv248
PMID
26123489
发布时间
2023-07-13
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Human molecular genetics
5285-98页
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