SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer.
作者:
主题词
动物(Animals);联苯化合物(Biphenyl Compounds);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);减量调节(Down-Regulation);抗药性, 肿瘤(Drug Resistance, Neoplasm);上皮-间质转化(Epithelial-Mesenchymal Transition);女(雌)性(Female);基因扩增(Gene Amplification);猬蛋白质类(Hedgehog Proteins);人类(Humans);肺肿瘤(Lung Neoplasms);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);原癌基因蛋白质c-met(Proto-Oncogene Proteins c-met);吡啶类(Pyridines);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);信号传导(Signal Transduction)
DOI
10.1158/1078-0432.CCR-14-3319
PMID
26124204
发布时间
2022-03-21
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Clinical cancer research
4686-97页
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