Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.

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作者： François,Gessier ^[1] ; Joerg,Kallen ^[1] ; Edgar,Jacoby ^[1] ; Patrick,Chène ^[1] ; Thérèse,Stachyra-Valat ^[1] ; Stephan,Ruetz ^[1] ; Sébastien,Jeay ^[1] ; Philipp,Holzer ^[1] ; Keiichi,Masuya ^[1] ; Pascal,Furet ^[2]

作者单位： Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland. ^[1] Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland. Electronic address: pascal.furet@novartis.com. ^[2]

关键词 MDM2 Protein–protein interaction inhibitors p53

主题词结晶学, X线(Crystallography, X-Ray);人类(Humans);异喹啉类(Isoquinolines);蛋白质结合(Protein Binding);原癌基因蛋白质c-mdm2(Proto-Oncogene Proteins c-mdm2);构效关系(Structure-Activity Relationship);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1016/j.bmcl.2015.06.058

PMID 26141769

发布时间 2022-03-30

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