首页> Journal of chromatography. B, Analytical technologies in the biomedical and life sciences> Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study.

Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study.

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第一作者： Lei,Yin

第一单位： Clinical Pharmacology Center, Research Institute of Translational Medicine, The First Hospital of Jilin University, Dongminzhu Street, Changchun 130061, PR China; College of Life Science, Jilin University, Qianjin Street, Changchun 130012, PR China; Research Center for Drug Metabolism, Jilin University, Qianjin Street, Changchun 130012, PR China.

作者： Lei,Yin ^[1] ; Xiangjun,Meng ^[2] ; Xiaotong,Zhou ^[2] ; Tinglan,Zhang ^[3] ; Heping,Sun ^[2] ; Zhichao,Yang ^[2] ; Bo,Yang ^[2] ; Ning,Xiao ^[4] ; J Paul,Fawcett ^[5] ; Yan,Yang ^[6] ; Jingkai,Gu ^[7]

作者单位： Clinical Pharmacology Center, Research Institute of Translational Medicine, The First Hospital of Jilin University, Dongminzhu Street, Changchun 130061, PR China; College of Life Science, Jilin University, Qianjin Street, Changchun 130012, PR China; Research Center for Drug Metabolism, Jilin University, Qianjin Street, Changchun 130012, PR China. ^[1] College of Life Science, Jilin University, Qianjin Street, Changchun 130012, PR China; Research Center for Drug Metabolism, Jilin University, Qianjin Street, Changchun 130012, PR China. ^[2] Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China. ^[3] College of Life Science, Jilin University, Qianjin Street, Changchun 130012, PR China. ^[4] School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand. ^[5] College of Life Science, Jilin University, Qianjin Street, Changchun 130012, PR China; Research Center for Drug Metabolism, Jilin University, Qianjin Street, Changchun 130012, PR China. Electronic address: yyan@jlu.edu.cn. ^[6] Clinical Pharmacology Center, Research Institute of Translational Medicine, The First Hospital of Jilin University, Dongminzhu Street, Changchun 130061, PR China; College of Life Science, Jilin University, Qianjin Street, Changchun 130012, PR China; Research Center for Drug Metabolism, Jilin University, Qianjin Street, Changchun 130012, PR China. Electronic address: gujk@mail.jlu.edu.cn. ^[7]

关键词 Carboprost Carboprost methylate Dog Esterase inhibitors LC–MS/MS Pharmacokinetics Prodrug

医学主题词动物(Animals);卡波前列素(Carboprost);色谱法, 液相(Chromatography, Liquid);狗(Dogs);女(雌)性(Female);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization);串联质谱法(Tandem Mass Spectrometry)

DOI 10.1016/j.jchromb.2015.05.039

PMID 26149245

发布时间 2019-12-10

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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2015年998-999卷

8-14页

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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2015年998-999卷

8-14页

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Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

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Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

相似文献

同项目论文

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

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