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The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis.

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第一作者: Mithun,Sharma
第一单位: Department of Hepatology and Nutrition, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
作者单位: Department of Hepatology and Nutrition, Asian Institute of Gastroenterology, Hyderabad, Telangana, India. [1] Research Labs, Institute of Basic Sciences and Translational Research, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, India. [2] Department of Genetics, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, India. [3] Department of Molecular Biology, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, India. [4] Department of Gastroenterology, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, India. [5] Department of Hepatology and Nutrition, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, India. [6]
关键词 AGE, Advanced glycation end productsALT, Alanine aminotransferaseAMPK, AMP-activated protein KinaseAPPL1 and 2, Adaptor protein 1 and 2ATP, Adenosine tri-phosphataseBMI, Basal Metabolic IndexCD, Cluster of differentiationCOL13A1, Collagen, type XIII, alpha 1DAMP, Damage assocauted molecular pattern moleculesEFCAB4B, EF-hand calcium binding domain 4BFA, Fatty acidFDFT1, Farnesyl-diphosphate farnesyltransferase 1FFA, Free fatty acidGCKR, Glucokinase regulatory proteinGLUT 5, Glucose transporter type 5GWAS, Genome wide association studiesHDL, High density lipoproteinHMGB1, High-mobility group protein B1HOMA-IR, Homoestatic model assessment-insulin resistanceHSC, Hepatic Stellate CellsHh, HedgehogIL6, Interleukin 6IR, Insulin ResistanceKC, Kupffer CellsLPS, LipopolysacharridesLYPLAL1, Lypophospholipase like 1MCP, Monocyte chemotactic proteinNAD, Nicotinamide adenine dinucleotideNAFL, Nonalcoholic fatty liverNAFLD, Nonalcoholic fatty liver diseaseNASH, Nonalcoholic steatohepatitisNCAN, Neurocan geneNF-KB, Nuclear Factor Kappa BNK, Natural KillerNKL, Natural Killer T cellsNLR, NOD like receptorNNMT, Nicotinamide N-methyltransferase geneOXLAM, Oxidized linolenic acid metabolitePAMP, Pathogen-associated Molecular patternPARVB, Beta Parvin GenePDGF, Platelet-derived growth factorPNPLA3PNPLA3, Patatin-like phospholipase domain-containing protein 3PPAR-α, Peroxisome proliferator activated receptor alphaPPP1R3B, Protein phosphatase 1 R3BPUFA, Poly unsaturated fatty acidPZP, Pregnancy-zone proteinROS, Reactive oxygen speciesSAMM, Sorting and assembly machinery componentSCAP, SREBP cleavage-activating proteinSFA, Saturated fatty acidSNP, Single nucleotide polymorphismSOCS3, Suppressor of cytokine signaling 3SOD2, Superoxide dismutase 2 geneSREBP-1C, Sterol regulatory Element—Binding Protein 1-C geneTLR, Toll like receptorTNF α, Tumor necrosis factor AlphaUCP3, Uncoupling protein 3 geneadiponectincytokinesgut microbiotalipotoxicity
DOI 10.1016/j.jceh.2015.02.002
PMID 26155043
发布时间 2022-03-11
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Journal of clinical and experimental hepatology

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