Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: synthesis, biological evaluation and molecular modeling studies.

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作者： Anna,Matys ^[1] ; Sabina,Podlewska ^[2] ; Karolina,Witek ^[1] ; Jagna,Witek ^[3] ; Andrzej J,Bojarski ^[3] ; Jakub,Schabikowski ^[1] ; Ewa,Otrębska-Machaj ^[1] ; Gniewomir,Latacz ^[1] ; Ewa,Szymańska ^[1] ; Katarzyna,Kieć-Kononowicz ^[1] ; Joseph,Molnar ^[4] ; Leonard,Amaral ^[5] ; Jadwiga,Handzlik ^[6]

作者单位： Department of Technology and Biotechnology of Drugs Jagiellonian University Medical College, Medyczna 9, PL 30-688 Kraków, Poland. ^[1] Department of Medicinal Chemistry Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland; Faculty of Chemistry Jagiellonian University, Ingardena 3, PL 30-060 Kraków, Poland. ^[2] Department of Medicinal Chemistry Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland. ^[3] Institute of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary. ^[4] Travel Medicine of the Centro de Malaria & Otra Doencas Tropicais (CMDT), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 100, 1349-008 Lisbon, Portugal. ^[5] Department of Technology and Biotechnology of Drugs Jagiellonian University Medical College, Medyczna 9, PL 30-688 Kraków, Poland. Electronic address: j.handzlik@uj.edu.pl. ^[6]

关键词 Arylideneimidazolidine-2,4-dione Arylideneimidazolone MRSA MecR1 Naphthylhydantoin PBP2a Staphylococcus aureus