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Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.

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第一作者： Nicholas,Douris

第一单位： Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

作者： Nicholas,Douris ^[1] ; Tamar,Melman ^[2] ; Jordan M,Pecherer ^[1] ; Pavlos,Pissios ^[1] ; Jeffrey S,Flier ^[1] ; Lewis C,Cantley ^[3] ; Jason W,Locasale ^[4] ; Eleftheria,Maratos-Flier ^[5]

作者单位： Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. ^[1] Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. ^[2] Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. ^[3] Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA. ^[4] Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: emaratos@bidmc.harvard.edu. ^[5]

关键词 Free fatty acid metabolism Hepatic steatosis Ketogenesis Ketogenic diet Liver Mass spectrometry Metabolomics

DOI 10.1016/j.bbadis.2015.07.009

PMID 26170063

发布时间 2019-11-20

基金项目

S10 RR023791/RR/NCRR NIH HHS/United States R01 DK083694/DK/NIDDK NIH HHS/United States R01 DK028082/DK/NIDDK NIH HHS/United States R00 CA168997/CA/NCI NIH HHS/United States R37 DK028082/DK/NIDDK NIH HHS/United States R01 GM041890/GM/NIGMS NIH HHS/United States T32 DK007516/DK/NIDDK NIH HHS/United States

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