Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio.

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第一作者： Jingwen,Yi

第一单位： National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.

作者： Jingwen,Yi ^[1] ; Xiaoguang,Yang ^[2] ; Lihua,Zheng ^[1] ; Guang,Yang ^[3] ; Luguo,Sun ^[1] ; Yongli,Bao ^[1] ; Yin,Wu ^[1] ; Yanxin,Huang ^[1] ; Chunlei,Yu ^[1] ; Shao-Nian,Yang ^[4] ; Yuxin,Li ^[5]

作者单位： National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. ^[1] School of Chemistry, Northeast Normal University, Changchun 130024, China liyx486@nenu.edu.cn yangxg168@nenu.edu.cn shao-nian.yang@ki.se. ^[2] Jilin Academy of Traditional Chinese Medicine, Changchun 130012, China. ^[3] National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden liyx486@nenu.edu.cn yangxg168@nenu.edu.cn shao-nian.yang@ki.se. ^[4] National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China liyx486@nenu.edu.cn yangxg168@nenu.edu.cn shao-nian.yang@ki.se. ^[5]

关键词 anti-cancer cell destruction cell growth hypericum perforatum pancreatic endocrine tumour photopharmacology