Discovery of 11β-hydroxysteroid dehydrogenase type 1 inhibitor.

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第一作者： Sung Pyo,Hong

第一单位： Institute for New Drug Development, Division of Life Sciences, Incheon National University, Incheon 406-772, Republic of Korea.

作者： Sung Pyo,Hong ^[1] ; Ky Youb,Nam ^[2] ; Young June,Shin ^[3] ; Kil Won,Kim ^[1] ; Soon Kil,Ahn ^[4]

作者单位： Institute for New Drug Development, Division of Life Sciences, Incheon National University, Incheon 406-772, Republic of Korea. ^[1] Center for Development and Commercialization of Anti Cancer Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, 138-736, Republic of Korea. ^[2] R & D Center, Ahn Gook Pharm., Suwon 443-766, Republic of Korea. ^[3] Institute for New Drug Development, Division of Life Sciences, Incheon National University, Incheon 406-772, Republic of Korea. Electronic address: skahn@incheon.ac.kr. ^[4]

关键词 11-β-Hydroxysteroid dehydrogenase (11β-HSD1) inhibitor Adamantane sulfonamide Antidiabetes Optimization Structure-based molecular modeling

主题词 11-β-羟甾脱氢酶1型(11-beta-Hydroxysteroid Dehydrogenase Type 1);动物(Animals);人类(Humans);小鼠(Mice);模型, 分子(Models, Molecular);分子结构(Molecular Structure);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2015.06.099

PMID 26187704

发布时间 2015-08-03

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