Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-ĸB-dependent mechanism.

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作者： Laura,Díaz ^[1] ; Marta,Martínez-Bonet ^[1] ; Javier,Sánchez ^[1] ; Alejandra,Fernández-Pineda ^[1] ; José Luis,Jiménez ^[1] ; Eduardo,Muñoz ^[2] ; Santiago,Moreno ^[3] ; Susana,Álvarez ^[1] ; Ma Ángeles,Muñoz-Fernández ^[1]

作者单位： Laboratorio InmunoBiología Molecular, Plataforma de Laboratorio, Hospital General Universitario Gregorio Marañón; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN). ^[1] Department of Cell Biology, Physiology and Immunology, Instituto Maimónides de Investigaciones Biomédicas de Córdoba (IMIBIC)/Reina Sofia University Hospital/University of Córdoba, Córdoba, Spain. ^[2] Departamento de Enfermedades Infecciosas, Hospital Universitario Ramón y Cajal, and IRYCIS. ^[3]

主题词星形细胞(Astrocytes);草苔虫素类(Bryostatins);细胞系, 肿瘤(Cell Line, Tumor);基因表达调控, 病毒(Gene Expression Regulation, Viral);HIV感染(HIV Infections);HIV长末端重复序列(HIV Long Terminal Repeat);HIV-1(HIV-1);人类(Humans);NF-κB(NF-kappa B);启动区, 遗传(Promoter Regions, Genetic);蛋白激酶C(Protein Kinase C);信号传导(Signal Transduction);转录激活(Transcriptional Activation);病毒潜伏期(Virus Latency)

DOI 10.1038/srep12442

PMID 26199173

发布时间 2018-11-13

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Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-ĸB-dependent mechanism.

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Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-ĸB-dependent mechanism.

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