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Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.

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第一作者： Mathieu,Bourdenx

第一单位： University de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France.;CNRS, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France.

作者： Mathieu,Bourdenx ^[1] ; Sandra,Dovero ^[1] ; Michel,Engeln ^[1] ; Simone,Bido ^[1] ; Matthieu F,Bastide ^[1] ; Nathalie,Dutheil ^[1] ; Isabel,Vollenweider ^[2] ; Laetitia,Baud ^[2] ; Camille,Piron ^[1] ; Virginie,Grouthier ^[1] ; Thomas,Boraud ^[1] ; Grégory,Porras ^[3] ; Qin,Li ^[4] ; Veerle,Baekelandt ^[5] ; Dieter,Scheller ^[6] ; Anne,Michel ^[6] ; Pierre-Olivier,Fernagut ^[1] ; François,Georges ^[7] ; Grégoire,Courtine ^[2] ; Erwan,Bezard ^[8] ; Benjamin,Dehay ^[9]

作者单位： University de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France.;CNRS, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France. ^[1] International Paraplegic Foundation chair in spinal cord Repair, Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. ^[2] Motac Neuroscience, Manchester, UK. ^[3] Motac Neuroscience, Manchester, UK.;Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing, China. ^[4] Department of Neurosciences and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, Laboratory for Neurobiology and Gene Therapy, Kapucijnenvoer 33, box 7001, 3000, Leuven, Belgium. ^[5] Parkinson's Disease Pharmacology, UCB Pharma S.A., Braine L'Alleud, B-1420, Belgium. ^[6] University de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR5297, Bordeaux, France.;CNRS, Institut Interdisciplinaire de Neurosciences, UMR 5297, F-33000, Bordeaux, France. ^[7] University de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France. erwan.bezard@u-bordeaux.fr.;CNRS, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France. erwan.bezard@u-bordeaux.fr. ^[8] University de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France. benjamin.dehay@u-bordeaux.fr.;CNRS, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France. benjamin.dehay@u-bordeaux.fr. ^[9]

医学主题词衰老(Aging);动物(Animals);狨猴属(Callithrix);疾病模型, 动物(Disease Models, Animal);多巴胺质膜转运蛋白质类(Dopamine Plasma Membrane Transport Proteins);绿色荧光蛋白质类(Green Fluorescent Proteins);人类(Humans);MPTP中毒(MPTP Poisoning);小鼠(Mice);运动活动(Motor Activity);主成分分析(Principal Component Analysis);精神运动性行为(Psychomotor Performance);大鼠(Rats);纹状体黑质变性(Striatonigral Degeneration);黑质(Substantia Nigra);时间因素(Time Factors);转导, 遗传(Transduction, Genetic);酪氨酸单氧化酶(Tyrosine 3-Monooxygenase);α突触核蛋白(alpha-Synuclein)

DOI 10.1186/s40478-015-0222-2

PMID 26205255

发布时间 2018-11-13

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Acta neuropathologica communications

2015年3卷

46页

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Acta neuropathologica communications

2015年3卷

46页

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Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.

Acta neuropathologica communications

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Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.

Acta neuropathologica communications

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Acta neuropathologica communications

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