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Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

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作者: Martin Hrabě,de Angelis [1] ; George,Nicholson [2] ; Mohammed,Selloum [3] ; Jacqui,White [4] ; Hugh,Morgan [5] ; Ramiro,Ramirez-Solis [6] ; Tania,Sorg [7] ; Sara,Wells [8] ; Helmut,Fuchs [9] ; Martin,Fray [10] ; David J,Adams [9] ; Niels C,Adams [5] ; Thure,Adler [6] ; Antonio,Aguilar-Pimentel [7] ; Dalila,Ali-Hadji [8] ; Gregory,Amann [10] ; Philippe,André [1] ; Sarah,Atkins [10] ; Aurelie,Auburtin [9] ; Abdel,Ayadi [9] ; Julien,Becker [1] ; Lore,Becker [11] ; Elodie,Bedu [1] ; Raffi,Bekeredjian [12] ; Marie-Christine,Birling [5] ; Andrew,Blake [6] ; Joanna,Bottomley [7] ; Mike,Bowl [8] ; Véronique,Brault [5] ; Dirk H,Busch [6] ; James N,Bussell [7] ; Julia,Calzada-Wack [8] ; Heather,Cater [5] ; Marie-France,Champy [6] ; Philippe,Charles [7] ; Claire,Chevalier [8] ; Francesco,Chiani [10] ; Gemma F,Codner [5] ; Roy,Combe [6] ; Roger,Cox [7] ; Emilie,Dalloneau [8] ; André,Dierich [5] ; Armida,Di Fenza [6] ; Brendan,Doe [7] ; Arnaud,Duchon [8] ; Oliver,Eickelberg [5] ; Chris T,Esapa [6] ; Lahcen,El Fertak [7] ; Tanja,Feigel [8] ; Irina,Emelyanova [1] ; Jeanne,Estabel [13] ; Jack,Favor [5] ; Ann,Flenniken [6] ; Alessia,Gambadoro [7] ; Lilian,Garrett [8] ; Hilary,Gates [1] ; Anna-Karin,Gerdin [14] ; George,Gkoutos [5] ; Simon,Greenaway [6] ; Lisa,Glasl [7] ; Patrice,Goetz [8] ; Isabelle Goncalves,Da Cruz [10] ; Alexander,Götz [9] ; Jochen,Graw [10] ; Alain,Guimond [15] ; Wolfgang,Hans [6] ; Geoff,Hicks [7] ; Sabine M,Hölter [8] ; Heinz,Höfler [11] ; John M,Hancock [9] ; Robert,Hoehndorf [16] ; Tertius,Hough [10] ; Richard,Houghton [5] ; Anja,Hurt [6] ; Boris,Ivandic [7] ; Hughes,Jacobs [8] ; Sylvie,Jacquot [5] ; Nora,Jones [6] ; Natasha A,Karp [7] ; Hugo A,Katus [8] ; Sharon,Kitchen [15] ; Tanja,Klein-Rodewald [6] ; Martin,Klingenspor [7] ; Thomas,Klopstock [8] ; Valerie,Lalanne [17] ; Sophie,Leblanc [10] ; Christoph,Lengger [5] ; Elise,le Marchand [6] ; Tonia,Ludwig [7] ; Aline,Lux [8] ; Colin,McKerlie [10] ; Holger,Maier [15] ; Jean-Louis,Mandel [6] ; Susan,Marschall [7] ; Manuel,Mark [8] ; David G,Melvin [5] ; Hamid,Meziane [6] ; Kateryna,Micklich [7] ; Christophe,Mittelhauser [8] ; Laurent,Monassier [10] ; David,Moulaert [17] ; Stéphanie,Muller [15] ; Beatrix,Naton [6] ; Frauke,Neff [7] ; Patrick M,Nolan [8] ; Lauryl Mj,Nutter [18] ; Markus,Ollert [10] ; Guillaume,Pavlovic [5] ; Natalia S,Pellegata [6] ; Emilie,Peter [7] ; Benoit,Petit-Demoulière [8] ; Amanda,Pickard [10] ; Christine,Podrini [10] ; Paul,Potter [9] ; Laurent,Pouilly [19] ; Oliver,Puk [20] ; David,Richardson [17] ; Stephane,Rousseau [21] ; Leticia,Quintanilla-Fend [10] ; Mohamed M,Quwailid [9] ; Ildiko,Racz [22] ; Birgit,Rathkolb [10] ; Fabrice,Riet [21] ; Janet,Rossant [5] ; Michel,Roux [6] ; Jan,Rozman [7] ; Ed,Ryder [8] ; Jennifer,Salisbury [5] ; Luis,Santos [6] ; Karl-Heinz,Schäble [7] ; Evelyn,Schiller [8] ; Anja,Schrewe [18] ; Holger,Schulz [21] ; Ralf,Steinkamp [5] ; Michelle,Simon [6] ; Michelle,Stewart [7] ; Claudia,Stöger [8] ; Tobias,Stöger [1] ; Minxuan,Sun [23] ; David,Sunter [21] ; Lydia,Teboul [13] ; Isabelle,Tilly [10] ; Glauco P,Tocchini-Valentini [24] ; Monica,Tost [10] ; Irina,Treise [9] ; Laurent,Vasseur [1] ; Emilie,Velot [1] ; Daniela,Vogt-Weisenhorn [14] ; Christelle,Wagner [5] ; Alison,Walling [6] ; Bruno,Weber [7] ; Olivia,Wendling [8] ; Henrik,Westerberg [5] ; Monja,Willershäuser [6] ; Eckhard,Wolf [7] ; Anne,Wolter [8] ; Joe,Wood [20] ; Wolfgang,Wurst [9] ; Ali Önder,Yildirim [1] ; Ramona,Zeh [14] ; Andreas,Zimmer [10] ; Annemarie,Zimprich [16] ; EUMODIC Consortium [1] ; Chris,Holmes [25] ; Karen P,Steel [1] ; Yann,Herault [13] ; Valérie,Gailus-Durner [5] ; Ann-Marie,Mallon [6] ; Steve Dm,Brown [7]
作者单位: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany. [1] School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany. [2] German Center for Diabetes Research (DZD), Neuherberg, Germany. [3] Department of Statistics, University of Oxford, Oxford, UK. [4] Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France. [5] Centre National de la Recherche Scientifique, Illkirch, France. [6] Institut National de la Santé et de la Recherche Médicale, Illkirch, France. [7] Université de Strasbourg, Illkirch, France. [8] The Wellcome Trust Sanger Institute, Hinxton, UK. [9] MRC Harwell, Medical Research Council, Harwell, UK. [10] Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany. [11] Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München/ Technische Universität München, and Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, Technische Universität München, Munich, Germany. [12] Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany. [13] Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany. [14] Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France. [15] Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany. [16] Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy. [17] Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany. [18] Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany. [19] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. [20] Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany. [21] Department of Computer Science, University of Aberystwyth, UK. [22] Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada. [23] Computational Bioscience Research Center, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia. [24] Else Kröner-Fresenius Center for Nutrional Medicine, Technische Universität München, Freising-Weihenstephan, Germany. [25] Toronto Centre for Phenogenomics, Toronto, Canada. [26] The Hospital for Sick Children, Toronto, Canada. [27] Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany. [28] Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany. [29] Max-Planck-Institute of Psychiatry, Munich, Germany. [30] Deutsches Zentrum für Neurodegenerative Erkrankungen, Munich, Germany. [31]
DOI 10.1038/ng.3360
PMID 26214591
发布时间 2022-01-29
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