换一批Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
第一作者：
Martin Hrabě,de Angelis
第一单位：
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.;School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.;German Center for Diabetes Research (DZD), Neuherberg, Germany.
作者：
Martin Hrabě,de Angelis [1]
;
George,Nicholson [2]
;
Mohammed,Selloum [3]
;
Jacqui,White [4]
;
Hugh,Morgan [5]
;
Ramiro,Ramirez-Solis [4]
;
Tania,Sorg [3]
;
Sara,Wells [5]
;
Helmut,Fuchs [6]
;
Martin,Fray [5]
;
David J,Adams [4]
;
Niels C,Adams [4]
;
Thure,Adler [7]
;
Antonio,Aguilar-Pimentel [8]
;
Dalila,Ali-Hadji [3]
;
Gregory,Amann [3]
;
Philippe,André [3]
;
Sarah,Atkins [5]
;
Aurelie,Auburtin [3]
;
Abdel,Ayadi [3]
;
Julien,Becker [3]
;
Lore,Becker [9]
;
Elodie,Bedu [3]
;
Raffi,Bekeredjian [10]
;
Marie-Christine,Birling [3]
;
Andrew,Blake [5]
;
Joanna,Bottomley [4]
;
Mike,Bowl [5]
;
Véronique,Brault [11]
;
Dirk H,Busch [12]
;
James N,Bussell [4]
;
Julia,Calzada-Wack [13]
;
Heather,Cater [5]
;
Marie-France,Champy [3]
;
Philippe,Charles [3]
;
Claire,Chevalier [11]
;
Francesco,Chiani [14]
;
Gemma F,Codner [5]
;
Roy,Combe [3]
;
Roger,Cox [5]
;
Emilie,Dalloneau [11]
;
André,Dierich [3]
;
Armida,Di Fenza [5]
;
Brendan,Doe [14]
;
Arnaud,Duchon [11]
;
Oliver,Eickelberg [15]
;
Chris T,Esapa [5]
;
Lahcen,El Fertak [3]
;
Tanja,Feigel [5]
;
Irina,Emelyanova [5]
;
Jeanne,Estabel [4]
;
Jack,Favor [16]
;
Ann,Flenniken [17]
;
Alessia,Gambadoro [14]
;
Lilian,Garrett [18]
;
Hilary,Gates [5]
;
Anna-Karin,Gerdin [4]
;
George,Gkoutos [19]
;
Simon,Greenaway [5]
;
Lisa,Glasl [18]
;
Patrice,Goetz [3]
;
Isabelle Goncalves,Da Cruz [3]
;
Alexander,Götz [15]
;
Jochen,Graw [18]
;
Alain,Guimond [3]
;
Wolfgang,Hans [6]
;
Geoff,Hicks [20]
;
Sabine M,Hölter [18]
;
Heinz,Höfler [21]
;
John M,Hancock [5]
;
Robert,Hoehndorf [22]
;
Tertius,Hough [5]
;
Richard,Houghton [4]
;
Anja,Hurt [6]
;
Boris,Ivandic [10]
;
Hughes,Jacobs [3]
;
Sylvie,Jacquot [3]
;
Nora,Jones [17]
;
Natasha A,Karp [4]
;
Hugo A,Katus [10]
;
Sharon,Kitchen [5]
;
Tanja,Klein-Rodewald [13]
;
Martin,Klingenspor [23]
;
Thomas,Klopstock [9]
;
Valerie,Lalanne [3]
;
Sophie,Leblanc [3]
;
Christoph,Lengger [6]
;
Elise,le Marchand [3]
;
Tonia,Ludwig [6]
;
Aline,Lux [3]
;
Colin,McKerlie [24]
;
Holger,Maier [6]
;
Jean-Louis,Mandel [25]
;
Susan,Marschall [6]
;
Manuel,Mark [25]
;
David G,Melvin [4]
;
Hamid,Meziane [3]
;
Kateryna,Micklich [6]
;
Christophe,Mittelhauser [3]
;
Laurent,Monassier [3]
;
David,Moulaert [3]
;
Stéphanie,Muller [3]
;
Beatrix,Naton [6]
;
Frauke,Neff [13]
;
Patrick M,Nolan [5]
;
Lauryl Mj,Nutter [26]
;
Markus,Ollert [8]
;
Guillaume,Pavlovic [3]
;
Natalia S,Pellegata [13]
;
Emilie,Peter [3]
;
Benoit,Petit-Demoulière [3]
;
Amanda,Pickard [5]
;
Christine,Podrini [4]
;
Paul,Potter [5]
;
Laurent,Pouilly [3]
;
Oliver,Puk [18]
;
David,Richardson [4]
;
Stephane,Rousseau [3]
;
Leticia,Quintanilla-Fend [13]
;
Mohamed M,Quwailid [5]
;
Ildiko,Racz [27]
;
Birgit,Rathkolb [28]
;
Fabrice,Riet [3]
;
Janet,Rossant [26]
;
Michel,Roux [25]
;
Jan,Rozman [23]
;
Ed,Ryder [4]
;
Jennifer,Salisbury [4]
;
Luis,Santos [5]
;
Karl-Heinz,Schäble [6]
;
Evelyn,Schiller [6]
;
Anja,Schrewe [6]
;
Holger,Schulz [15]
;
Ralf,Steinkamp [6]
;
Michelle,Simon [5]
;
Michelle,Stewart [5]
;
Claudia,Stöger [6]
;
Tobias,Stöger [15]
;
Minxuan,Sun [18]
;
David,Sunter [4]
;
Lydia,Teboul [5]
;
Isabelle,Tilly [3]
;
Glauco P,Tocchini-Valentini [14]
;
Monica,Tost [13]
;
Irina,Treise [6]
;
Laurent,Vasseur [3]
;
Emilie,Velot [11]
;
Daniela,Vogt-Weisenhorn [18]
;
Christelle,Wagner [25]
;
Alison,Walling [5]
;
Bruno,Weber [3]
;
Olivia,Wendling [25]
;
Henrik,Westerberg [5]
;
Monja,Willershäuser [6]
;
Eckhard,Wolf [29]
;
Anne,Wolter [3]
;
Joe,Wood [5]
;
Wolfgang,Wurst [30]
;
Ali Önder,Yildirim [15]
;
Ramona,Zeh [6]
;
Andreas,Zimmer [27]
;
Annemarie,Zimprich [18]
;
EUMODIC Consortium [2]
;
Chris,Holmes [4]
;
Karen P,Steel [25]
;
Yann,Herault [6]
;
Valérie,Gailus-Durner [5]
;
Ann-Marie,Mallon [5]
;
Steve Dm,Brown
作者单位：
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.;School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.;German Center for Diabetes Research (DZD), Neuherberg, Germany.
[1]
Department of Statistics, University of Oxford, Oxford, UK.
[2]
Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.;Centre National de la Recherche Scientifique, Illkirch, France.;Institut National de la Santé et de la Recherche Médicale, Illkirch, France.;Université de Strasbourg, Illkirch, France.
[3]
The Wellcome Trust Sanger Institute, Hinxton, UK.
[4]
MRC Harwell, Medical Research Council, Harwell, UK.
[5]
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[6]
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.;Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
[7]
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.;Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München/ Technische Universität München, and Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
[8]
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.;Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.
[9]
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.;Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.
[10]
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.;Centre National de la Recherche Scientifique, Illkirch, France.;Institut National de la Santé et de la Recherche Médicale, Illkirch, France.;Université de Strasbourg, Illkirch, France.
[11]
Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
[12]
Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[13]
Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
[14]
Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[15]
Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[16]
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
[17]
Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[18]
Department of Computer Science, University of Aberystwyth, UK.
[19]
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
[20]
Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.
[21]
Computational Bioscience Research Center, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia.
[22]
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.;Else Kröner-Fresenius Center for Nutrional Medicine, Technische Universität München, Freising-Weihenstephan, Germany.
[23]
Toronto Centre for Phenogenomics, Toronto, Canada.;The Hospital for Sick Children, Toronto, Canada.
[24]
Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.;Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.;Centre National de la Recherche Scientifique, Illkirch, France.;Institut National de la Santé et de la Recherche Médicale, Illkirch, France.;Université de Strasbourg, Illkirch, France.
[25]
The Hospital for Sick Children, Toronto, Canada.
[26]
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.;Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany.
[27]
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.;Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany.
[28]
Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany.;German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[29]
Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.;School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.;Max-Planck-Institute of Psychiatry, Munich, Germany.;Deutsches Zentrum für Neurodegenerative Erkrankungen, Munich, Germany.
[30]
医学主题词
动物(Animals);女(雌)性(Female);遗传关联研究(Genetic Association Studies);杂合子(Heterozygote);纯合子(Homozygote);人类(Humans);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);分子序列注释(Molecular Sequence Annotation);突变(Mutation);表型(Phenotype)
DOI
10.1038/ng.3360
PMID
26214591
发布时间
2025-05-29
基金项目
MC_U142684175/MRC_/Medical Research Council/United Kingdom
MC_QA137918/MRC_/Medical Research Council/United Kingdom
MC_U142684171/MRC_/Medical Research Council/United Kingdom
MC_U142684172/MRC_/Medical Research Council/United Kingdom
MC_U142661184/MRC_/Medical Research Council/United Kingdom
MC_UP_1502/3/MRC_/Medical Research Council/United Kingdom
13031/CRUK_/Cancer Research UK/United Kingdom
084655/WT_/Wellcome Trust/United Kingdom
G0300212/MRC_/Medical Research Council/United Kingdom
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Nature genetics
Nature genetics
969-978页
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