Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
作者:
Martin Hrabě,de Angelis [1]
;
George,Nicholson [2]
;
Mohammed,Selloum [3]
;
Jacqui,White [4]
;
Hugh,Morgan [5]
;
Ramiro,Ramirez-Solis [6]
;
Tania,Sorg [7]
;
Sara,Wells [8]
;
Helmut,Fuchs [9]
;
Martin,Fray [10]
;
David J,Adams [9]
;
Niels C,Adams [5]
;
Thure,Adler [6]
;
Antonio,Aguilar-Pimentel [7]
;
Dalila,Ali-Hadji [8]
;
Gregory,Amann [10]
;
Philippe,André [1]
;
Sarah,Atkins [10]
;
Aurelie,Auburtin [9]
;
Abdel,Ayadi [9]
;
Julien,Becker [1]
;
Lore,Becker [11]
;
Elodie,Bedu [1]
;
Raffi,Bekeredjian [12]
;
Marie-Christine,Birling [5]
;
Andrew,Blake [6]
;
Joanna,Bottomley [7]
;
Mike,Bowl [8]
;
Véronique,Brault [5]
;
Dirk H,Busch [6]
;
James N,Bussell [7]
;
Julia,Calzada-Wack [8]
;
Heather,Cater [5]
;
Marie-France,Champy [6]
;
Philippe,Charles [7]
;
Claire,Chevalier [8]
;
Francesco,Chiani [10]
;
Gemma F,Codner [5]
;
Roy,Combe [6]
;
Roger,Cox [7]
;
Emilie,Dalloneau [8]
;
André,Dierich [5]
;
Armida,Di Fenza [6]
;
Brendan,Doe [7]
;
Arnaud,Duchon [8]
;
Oliver,Eickelberg [5]
;
Chris T,Esapa [6]
;
Lahcen,El Fertak [7]
;
Tanja,Feigel [8]
;
Irina,Emelyanova [1]
;
Jeanne,Estabel [13]
;
Jack,Favor [5]
;
Ann,Flenniken [6]
;
Alessia,Gambadoro [7]
;
Lilian,Garrett [8]
;
Hilary,Gates [1]
;
Anna-Karin,Gerdin [14]
;
George,Gkoutos [5]
;
Simon,Greenaway [6]
;
Lisa,Glasl [7]
;
Patrice,Goetz [8]
;
Isabelle Goncalves,Da Cruz [10]
;
Alexander,Götz [9]
;
Jochen,Graw [10]
;
Alain,Guimond [15]
;
Wolfgang,Hans [6]
;
Geoff,Hicks [7]
;
Sabine M,Hölter [8]
;
Heinz,Höfler [11]
;
John M,Hancock [9]
;
Robert,Hoehndorf [16]
;
Tertius,Hough [10]
;
Richard,Houghton [5]
;
Anja,Hurt [6]
;
Boris,Ivandic [7]
;
Hughes,Jacobs [8]
;
Sylvie,Jacquot [5]
;
Nora,Jones [6]
;
Natasha A,Karp [7]
;
Hugo A,Katus [8]
;
Sharon,Kitchen [15]
;
Tanja,Klein-Rodewald [6]
;
Martin,Klingenspor [7]
;
Thomas,Klopstock [8]
;
Valerie,Lalanne [17]
;
Sophie,Leblanc [10]
;
Christoph,Lengger [5]
;
Elise,le Marchand [6]
;
Tonia,Ludwig [7]
;
Aline,Lux [8]
;
Colin,McKerlie [10]
;
Holger,Maier [15]
;
Jean-Louis,Mandel [6]
;
Susan,Marschall [7]
;
Manuel,Mark [8]
;
David G,Melvin [5]
;
Hamid,Meziane [6]
;
Kateryna,Micklich [7]
;
Christophe,Mittelhauser [8]
;
Laurent,Monassier [10]
;
David,Moulaert [17]
;
Stéphanie,Muller [15]
;
Beatrix,Naton [6]
;
Frauke,Neff [7]
;
Patrick M,Nolan [8]
;
Lauryl Mj,Nutter [18]
;
Markus,Ollert [10]
;
Guillaume,Pavlovic [5]
;
Natalia S,Pellegata [6]
;
Emilie,Peter [7]
;
Benoit,Petit-Demoulière [8]
;
Amanda,Pickard [10]
;
Christine,Podrini [10]
;
Paul,Potter [9]
;
Laurent,Pouilly [19]
;
Oliver,Puk [20]
;
David,Richardson [17]
;
Stephane,Rousseau [21]
;
Leticia,Quintanilla-Fend [10]
;
Mohamed M,Quwailid [9]
;
Ildiko,Racz [22]
;
Birgit,Rathkolb [10]
;
Fabrice,Riet [21]
;
Janet,Rossant [5]
;
Michel,Roux [6]
;
Jan,Rozman [7]
;
Ed,Ryder [8]
;
Jennifer,Salisbury [5]
;
Luis,Santos [6]
;
Karl-Heinz,Schäble [7]
;
Evelyn,Schiller [8]
;
Anja,Schrewe [18]
;
Holger,Schulz [21]
;
Ralf,Steinkamp [5]
;
Michelle,Simon [6]
;
Michelle,Stewart [7]
;
Claudia,Stöger [8]
;
Tobias,Stöger [1]
;
Minxuan,Sun [23]
;
David,Sunter [21]
;
Lydia,Teboul [13]
;
Isabelle,Tilly [10]
;
Glauco P,Tocchini-Valentini [24]
;
Monica,Tost [10]
;
Irina,Treise [9]
;
Laurent,Vasseur [1]
;
Emilie,Velot [1]
;
Daniela,Vogt-Weisenhorn [14]
;
Christelle,Wagner [5]
;
Alison,Walling [6]
;
Bruno,Weber [7]
;
Olivia,Wendling [8]
;
Henrik,Westerberg [5]
;
Monja,Willershäuser [6]
;
Eckhard,Wolf [7]
;
Anne,Wolter [8]
;
Joe,Wood [20]
;
Wolfgang,Wurst [9]
;
Ali Önder,Yildirim [1]
;
Ramona,Zeh [14]
;
Andreas,Zimmer [10]
;
Annemarie,Zimprich [16]
;
EUMODIC Consortium [1]
;
Chris,Holmes [25]
;
Karen P,Steel [1]
;
Yann,Herault [13]
;
Valérie,Gailus-Durner [5]
;
Ann-Marie,Mallon [6]
;
Steve Dm,Brown [7]
作者单位:
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[1]
School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.
[2]
German Center for Diabetes Research (DZD), Neuherberg, Germany.
[3]
Department of Statistics, University of Oxford, Oxford, UK.
[4]
Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
[5]
Centre National de la Recherche Scientifique, Illkirch, France.
[6]
Institut National de la Santé et de la Recherche Médicale, Illkirch, France.
[7]
Université de Strasbourg, Illkirch, France.
[8]
The Wellcome Trust Sanger Institute, Hinxton, UK.
[9]
MRC Harwell, Medical Research Council, Harwell, UK.
[10]
Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
[11]
Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München/ Technische Universität München, and Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
[12]
Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.
[13]
Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.
[14]
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
[15]
Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[16]
Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
[17]
Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[18]
Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[19]
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
[20]
Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
[21]
Department of Computer Science, University of Aberystwyth, UK.
[22]
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
[23]
Computational Bioscience Research Center, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia.
[24]
Else Kröner-Fresenius Center for Nutrional Medicine, Technische Universität München, Freising-Weihenstephan, Germany.
[25]
Toronto Centre for Phenogenomics, Toronto, Canada.
[26]
The Hospital for Sick Children, Toronto, Canada.
[27]
Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany.
[28]
Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany.
[29]
Max-Planck-Institute of Psychiatry, Munich, Germany.
[30]
Deutsches Zentrum für Neurodegenerative Erkrankungen, Munich, Germany.
[31]
主题词
动物(Animals);女(雌)性(Female);遗传关联研究(Genetic Association Studies);杂合子(Heterozygote);纯合子(Homozygote);人类(Humans);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);分子序列注释(Molecular Sequence Annotation);突变(Mutation);表型(Phenotype)
DOI
10.1038/ng.3360
PMID
26214591
发布时间
2022-01-29
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Nature genetics
Nature genetics
969-978页
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