A Pharmacometabonomic Approach To Predicting Metabolic Phenotypes and Pharmacokinetic Parameters of Atorvastatin in Healthy Volunteers.

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作者： Qing,Huang ^[1] ; Jiye,Aa ^[2] ; Huning,Jia ^[1] ; Xiaoqing,Xin ^[1] ; Chunlei,Tao ^[3] ; Linsheng,Liu ^[1] ; Bingjie,Zou ^[3] ; Qinxin,Song ^[4] ; Jian,Shi ^[5] ; Bei,Cao ^[3] ; Yonghong,Yong ^[1] ; Guangji,Wang ^[1] ; Guohua,Zhou ^[1]

作者单位： China Pharmaceutical University, Nanjing 210009, China. ^[1] Jiangsu Institute for Food and Drug Control, Nanjing 210008, China. ^[2] Department of Pharmacology, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, China. ^[3] Anhui University of Chinese Medicine, Hefei 230038, China. ^[4] Clinical Pharmacology Research Laboratory, The First Affiliated Hospital of Soochow University , Suzhou 215006, China. ^[5] The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. ^[6]

关键词 atorvastatin metabolomics personalized medicine pharmacokinetics pharmacometabonomics precision medicine prediction

主题词成年人(Adult);曲线下面积(Area Under Curve);人类(Humans);最小二乘法分析(Least-Squares Analysis);男(雄)性(Male);代谢组学(Metabolomics);青年人(Young Adult)

DOI 10.1021/acs.jproteome.5b00440

PMID 26216528

发布时间 2022-03-10

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