Induction of p53-independent apoptosis by ectopic expression of HOXA5 in human liposarcomas.

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第一作者： Dhong Hyun,Lee

第一单位： Division of Hematology and Oncology, Departments of Surgery,Biomedical Sciences and Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute,Cedars-Sinai Medical Center, Los Angeles, CA, USA.

作者： Dhong Hyun,Lee ^[1] ; Charles,Forscher ^[1] ; Dolores,Di Vizio ^[2] ; H Phillip,Koeffler ^[3]

作者单位： Division of Hematology and Oncology, Departments of Surgery,Biomedical Sciences and Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute,Cedars-Sinai Medical Center, Los Angeles, CA, USA. ^[1] 1] Division of Cancer Biology and Therapeutics, Departments of Surgery, Biomedical Sciences and Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA [2] The Urological Diseases Research Center; Boston Children's Hospital, Boston, MA, Department of Surgery, Harvard Medical School, Boston, MA, USA. ^[2] 1] Division of Hematology and Oncology, Departments of Surgery,Biomedical Sciences and Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute,Cedars-Sinai Medical Center, Los Angeles, CA, USA [2] National Cancer Institute and Cancer Science Institute, National University of Singapore, Singapore. ^[3]

主题词细胞凋亡(Apoptosis);半胱氨酸天冬氨酸蛋白酶(Caspases);细胞分化(Cell Differentiation);细胞系, 肿瘤(Cell Line, Tumor);减量调节(Down-Regulation);基因扩增(Gene Amplification);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);同源盒结构域蛋白质类(Homeodomain Proteins);人类(Humans);脂肪肉瘤(Liposarcoma);微RNAs(MicroRNAs);NF-κB(NF-kappa B);转录激活(Transcriptional Activation);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);增量调节(Up-Regulation)

DOI 10.1038/srep12580

PMID 26219418

发布时间 2018-11-13

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Induction of p53-independent apoptosis by ectopic expression of HOXA5 in human liposarcomas.

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Induction of p53-independent apoptosis by ectopic expression of HOXA5 in human liposarcomas.

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