Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors.

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作者： Denis S,Kudryavtsev ^[1] ; Irina V,Shelukhina ^[1] ; Lina V,Son ^[2] ; Lucy O,Ojomoko ^[1] ; Elena V,Kryukova ^[1] ; Ekaterina N,Lyukmanova ^[3] ; Maxim N,Zhmak ^[4] ; Dmitry A,Dolgikh ^[3] ; Igor A,Ivanov ^[1] ; Igor E,Kasheverov ^[1] ; Vladislav G,Starkov ^[1] ; Joachim,Ramerstorfer ^[5] ; Werner,Sieghart ^[5] ; Victor I,Tsetlin ^[1] ; Yuri N,Utkin ^[6]

作者单位： From the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya Street, Moscow 117997, Russia. ^[1] the Moscow Institute of Physics and Technology, Institutsky Per. 9, Dolgoprudny, Moscow Region 141700, Russia. ^[2] From the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya Street, Moscow 117997, Russia, the Lomonosov Moscow State University, Moscow 119991, Russia, and. ^[3] From the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya Street, Moscow 117997, Russia, the Syneuro OOO, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia. ^[4] the Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, A-1090 Vienna, Austria. ^[5] From the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya Street, Moscow 117997, Russia, utkin@mx.ibch.ru. ^[6]

关键词 Cys-loop receptor GABAA receptor electrophysiology fluorescence molecular dynamics molecular modeling neurotoxin snake venom three finger toxin