VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.

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作者： Rajakrishnan,Veluthakal ^[1] ; Ragadeepthi,Tunduguru ^[2] ; Daleep Kumar,Arora ^[3] ; Vaibhav,Sidarala ^[4] ; Khadija,Syeda ^[1] ; Cornelis P,Vlaar ^[5] ; Debbie C,Thurmond ^[1] ; Anjaneyulu,Kowluru ^[5]

作者单位： Beta Cell Biochemistry Laboratory, John D. Dingell VA Medical Center, 4646 John R, Detroit, MI, 48201, USA. ^[1] Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. ^[2] Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. ^[3] Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA. ^[4] Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy, Wayne State University, Detroit, MI, USA. ^[5] Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico. ^[6] Beta Cell Biochemistry Laboratory, John D. Dingell VA Medical Center, 4646 John R, Detroit, MI, 48201, USA. akowluru@med.wayne.edu. ^[7] Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy, Wayne State University, Detroit, MI, USA. akowluru@med.wayne.edu. ^[8] B-4237 Research Service, John D. Dingell VA Medical Center, 4646 John R, Detroit, MI, 48201, USA. akowluru@med.wayne.edu. ^[9]

关键词 Cytoskeleton Insulin secretion Pancreatic islet Rac1 VAV2