Dual attenuation of proteasomal and autophagic BMAL1 degradation in Clock Δ19/+ mice contributes to improved glucose homeostasis.
第一作者:
Kwon,Jeong
第一单位:
Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030.
作者:
医学主题词
ARNTL转录因子类(ARNTL Transcription Factors);动物(Animals);自噬(Autophagy);血糖(Blood Glucose);时钟蛋白质类(CLOCK Proteins);昼夜节律(Circadian Rhythm);基因表达调控(Gene Expression Regulation);内环境稳定(Homeostasis);胰岛素(Insulin);肝(Liver);男(雄)性(Male);小鼠, 突变型(Mice, Mutant Strains);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex)
DOI
10.1038/srep12801
PMID
26228022
发布时间
2023-12-13
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