Phosphorylation of Tyrosine 1070 at the GluN2B Subunit Is Regulated by Synaptic Activity and Critical for Surface Expression of N-Methyl-D-aspartate (NMDA) Receptors.

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作者： Wen,Lu ^[1] ; Weiqing,Fang ^[1] ; Jian,Li ^[2] ; Bin,Zhang ^[1] ; Qian,Yang ^[1] ; Xunyi,Yan ^[1] ; Lin,Peng ^[1] ; Heng,Ai ^[3] ; Jie-jie,Wang ^[1] ; Xiao,Liu ^[1] ; Jianhong,Luo ^[4] ; Wei,Yang ^[5]

作者单位： From the Department of Neurobiology, Key Laboratory of Medical Neurobiology (Ministry of Health of China), Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China. ^[1] From the Department of Neurobiology, Key Laboratory of Medical Neurobiology (Ministry of Health of China), Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China, and. ^[2] Department of Physiology, Zhejiang Medical College, Hangzhou, Zhejiang 310053, China. ^[3] From the Department of Neurobiology, Key Laboratory of Medical Neurobiology (Ministry of Health of China), Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China, luojianhong@zju.edu.cn. ^[4] From the Department of Neurobiology, Key Laboratory of Medical Neurobiology (Ministry of Health of China), Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China, yangwei@zju.edu.cn. ^[5]

关键词 Fyn GluN2B N-methyl-d-aspartate receptor (NMDA receptor, NMDAR)Src Tyr-1070 phosphotyrosine signaling protein-protein interaction synaptic plasticity