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Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine.

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第一作者： Brendan M,Crowley

第一单位： Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, WP14-2, 770 Sumneytown Pike, West Point, PA 19486, USA. Electronic address: brendan_crowley@merck.com.

作者： Brendan M,Crowley ^[1] ; Craig A,Stump ^[2] ; Diem N,Nguyen ^[2] ; Craig M,Potteiger ^[2] ; Melody A,McWherter ^[2] ; Daniel V,Paone ^[2] ; Amy G,Quigley ^[2] ; Joseph G,Bruno ^[3] ; Dan,Cui ^[4] ; J Christopher,Culberson ^[5] ; Andrew,Danziger ^[6] ; Christine,Fandozzi ^[4] ; Danny,Gauvreau ^[7] ; Amanda L,Kemmerer ^[3] ; Karsten,Menzel ^[4] ; Eric L,Moore ^[8] ; Scott D,Mosser ^[3] ; Vijay,Reddy ^[9] ; Rebecca B,White ^[4] ; Christopher A,Salvatore ^[8] ; Stefanie A,Kane ^[8] ; Ian M,Bell ^[2] ; Harold G,Selnick ^[2] ; Mark E,Fraley ^[2] ; Christopher S,Burgey ^[2]

作者单位： Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, WP14-2, 770 Sumneytown Pike, West Point, PA 19486, USA. Electronic address: brendan_crowley@merck.com. ^[1] Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, WP14-2, 770 Sumneytown Pike, West Point, PA 19486, USA. ^[2] Department of In Vitro Pharmacology, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA. ^[3] Department of Pharmacokinetics Pharmacodynamics & Drug Metabolism, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA. ^[4] Department of Chemistry Modeling and Informatics, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA. ^[5] Department of In Vivo Pharmacology, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA. ^[6] Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec H9H 3L1, Canada. ^[7] Department of Pain & Migraine, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA. ^[8] Department of Genetic Tox & Molecular Carcinogenesis, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA. ^[9]

关键词 CGRP Class B GPCR Migraine Oxazolidinone Scaffold hopping